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Genetic factors affecting pregnancy duration in humans


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/57420

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Title: Genetic factors affecting pregnancy duration in humans
Authors: Bacelis, Jonas
E-mail: jonas.bacelis@gu.se
Issue Date: 1-Nov-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Obstetrics and Gynecology
Parts of work: Bacelis J, Juodakis J, Sengpiel V, Zhang G, Myhre R, Muglia LJ, Nilsson S, Jacobsson B. Literature-informed analysis of a genome-wide association study of gestational age in Norwegian women and children suggests involvement of inflammatory pathways. PLOS One, 2016. 11(8): e0160335.
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Zhang G, Bacelis J, Lengyel C, Teramo K, Hallman M, Helgeland Ø, Johansson S, Myhre R, Sengpiel V, Njølstad PR, Jacobsson B, Muglia L. Assessing the causal relationship of maternal height on birth size and gestational age at birth: a Mendelian randomization analysis. PLOS Medicine, 2015. 12(8): e1001865.
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Bacelis J, Juodakis J, Adams Waldorf KM, Sengpiel V, Muglia LJ, Zhang G, Jacobsson B. Uterine distention as a factor in birth timing: retrospective nationwide cohort study in Sweden. BMJ Open, 2018. 0:e022929
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Date of Defence: 2018-11-22
Disputation: hörsal Järneken, Östra Sjukhuset, Diagnosvägen 15, torsdagen den 22 november 2018, klockan 13.00
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: genomics
GWAS
Mendelian randomization
causality
preterm birth
pregnancy
gestation
height
Abstract: This thesis investigates the mechanisms behind human pregnancy duration. Too short gestation is a direct cause of perinatal, neonatal, and infant mortality. Deviation from normal pregnancy length is also associated with a child's morbidity, even in the adulthood. The mechanisms determining pregnancy duration are not understood well enough to design an effective preterm birth prevention method, nor a method that would prevent preterm birth sequelae. The three included studies use genomic and epid... more
ISBN: 978-91-7833-176-5 (PDF)
978-91-7833-175-8 (PRINT)
URI: http://hdl.handle.net/2077/57420
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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