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Cerebrospinal fluid peptidomics: discovery of endogenous peptides as biomarkers of Alzheimer's disease


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Title: Cerebrospinal fluid peptidomics: discovery of endogenous peptides as biomarkers of Alzheimer's disease
Authors: Hansson, Karl
E-mail: karl.hansson@neuro.gu.se
karl.hansson@neuro.gu.se
Issue Date: 2-Oct-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: Hansson K, Skillbäck T, Pernevik E, Kern S, Portelius E, Höglund K, Brinkmalm G, Holmén-Larsson J, Blennow K, Zetterberg H and Gobom J. Expanding the cerebrospinal fluid endopeptidome. Proteomics 2017, 17:5.
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Hansson K, Zetterberg H, Blennow K, and Gobom J. Turbulent flow chromatography for rapid cerebrospinal fluid sample preparation for clinical peptidomics in Alzheimer’s disease. Manuscript.

Skillbäck T, Mattsson N, Hansson K, Mirgorodskaya E, Dahlén R, van der Flier W, Scheltens P, Duits F, Hansson O, Teunissen C, Blennow K, Zetterberg H and Gobom J. A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer’s disease. Scientific Reports 2017, 7:1.
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IV. Hansson K, Dahlén R, Hansson O, Pernevik E, Paterson R W, Schott J M, Magdalinou N, Zetterberg H, Blennow,K and Gobom J. The protein-to-peptide ratio improves the performance of tau in CSF as a biomarker of Alzheimer’s disease. Manuscript submitted.
Date of Defence: 2018-10-19
Disputation: Fredagen den 19 oktober 2018, klockan 09:00, Hjärtats Aula, Sahlgrenska sjukhuset, Vita stråket 12
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Alzheimer's disease
Biomarkers
Mass spectrometry
Cerebrospinal fluid
Liquid Chromatography
Endogenous peptides
Abstract: Neurodegenerative diseases (NDs), the most prominent example of which is Alzheimer’s disease (AD), has turned out to be among the greatest challenges for modern medicine. Common characteristics of NDs involve the aggregation of proteins, progressive loss of neuronal cells in specific regions of the central nervous system (CNS) and as a result – cognitive and/or functional decline. Another common feature of most NDs is an extended prodromal stage, in the case of AD believed to be initiated over a... more
ISBN: 978-91-7833-157-4
978-91-7833-158-1
URI: http://hdl.handle.net/2077/56928
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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