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Cardiopulmonary bypass and the kidney - studies on patients undergoing cardiac surgery

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Title: Cardiopulmonary bypass and the kidney - studies on patients undergoing cardiac surgery
Authors: Lannemyr, Lukas
Issue Date: 12-Nov-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Anesthesiology & Intensive Care Medicine
Parts of work: I. Lannemyr L, Lundin E, Reinsfelt B, Bragadottir G, Redfors B, Oras J, Ricksten SE. Renal tubular injury during cardiopulmonary bypass as assessed by urinary release of N-acetyl-ß-D-glucosaminidase. Acta Anaesthesiologica Scandinavica. 2017;61(9):1075-1083.

II. Lannemyr L, Bragadottir G, Krumbholz V, Redfors B, Sellgren J, Ricksten SE. Effects of Cardiopulmonary Bypass on Renal Perfusion, Filtration, and Oxygenation in Patients Undergoing Cardiac Surgery. Anesthesiology, 2017;126(2):205-213.

III. Lannemyr L, Bragadottir G, Hjärpe A, Redfors B, Ricksten SE. Impact of cardiopulmonary bypass flow on renal oxygenation in patients undergoing cardiac surgery. Accepted for publication, Annals of Thoracic Surgery, August 2018

IV. Lannemyr L, Ricksten SE, Rundqvist B, Andersson B, Bartfay SE, Ljungman C, Dahlberg P, Bergh N, Hjalmarsson C, Gilljam T, Bollano E, Karason K. Differential effects of levosimendan and dobutamine on glomerular filtration rate in patients with heart failure and renal impairment: A randomized double-blind controlled trial. Journal of the American Heart Association. 2018;7: e008455.

Date of Defence: 2018-11-30
Disputation: Fredagen den 30 november 2018, kl. 9.00, sal Kammaren, Sahlgrenska Universitetssjukhuset, Blå Stråket 5, Göteborg.
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: cardiac surgery
cardiopulmonary bypass
glomerular filtration rate
renal blood flow
renal oxygenation
tubular injury
Abstract: Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass (CPB), and has a major impact on morbidity, mortality and costs. The mechanism of CPB-related renal impairment is not fully understood. The aim of this thesis was to describe how CPB affects the kidneys, and whether increased CPB flow might improve renal oxygenation. In addition, we compared the systemic and renal effects of two inotropes in patients with impaired cardiac and renal function. Methods: ... more
ISBN: 978-91-7833-181-9
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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