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Microbial modulation of metabolic diseases

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Title: Microbial modulation of metabolic diseases
Authors: Molinaro, Antonio
Issue Date: 13-Sep-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: Host-microbiota interaction induces bi-phasic inflammation and glucose intolerance in mice. Molinaro A, Caesar R, Holm LM, Tremaroli V, Cani PD, Bäckhed F. Mol Metab. 2017 Nov;6(11):1371-1380.

Microbially produced imidazole propionate impairs insulin signaling through mTORC1. Koh A, Molinaro A, Ståhlman M, Khan MT, Schmidt C, Mannerås-Holm L, Wu H, Carreras A, Jeong H, Olofsson L, Bergh PO, Gerdes V, Hartstra A, de Brauw M, Perkins R, Nieuwdorp M, Bergström G, Bäckhed F. Manuscript.

Steatosis is associated with altered microbiome in humans. Molinaro A, Wu H, Schoenauer US, Datz C, Bergström G, Marschall HU, Tilg H, Tremaroli V, Bäckhed F. Manuscript.
Date of Defence: 2018-10-19
Disputation: 19th October 9:00, Arvid Carlsson Lecture Hall
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Microbiota
Glucose Metabolism
type 2 diabetes
non-alcoholic fatty liver disease
Abstract: The gut microbiota, the ensemble of microorganisms living in the gastrointestinal tract, and the host have a mutualist relationship. Alterations of this delicate equilibrium can lead to changes in microbiota composition and/or function leading to the onset of metabolic diseases (e.g., type 2 diabetes and non-alcoholic fatty liver diseases). The current knowledge of host-microbiota interaction, in health and disease, is limited. Here, by using a translational science approach, we were able to ide... more
ISBN: 978-91-7833-137-6 (PRINT)
978-91-7833-138-3 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin



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