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Biomarkers in Multiple Sclerosis - Monitoring disease activity and treatment afficacy


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Title: Biomarkers in Multiple Sclerosis - Monitoring disease activity and treatment afficacy
Authors: Nováková Nyrén, Lenka
E-mail: lenka.novakova@vgregion.se
Issue Date: 21-Mar-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Clinical Neuroscience and Rehabilitation
Parts of work: I. Novakova L, Axelsson M, Malmeström C, Zetterberg H, Björkhem I, Karren-bauer VD, Lycke J. Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis. Journal of Neurological Sciences 2015; 358(1-2): 201-206
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II. Novakova L, Axelsson M, Khademi M, Zetterberg H, Blennow K, Malmeström C, Piehl F, Olsson T, Lycke J. Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing-remitting multiple sclerosis. Journal of Neurochemistry 2017; 141(2): 296-304
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III. Novakova L, Axelsson M, Khademi M, Zetterberg H, Blennow K, Malmeström C, Piehl F, Olsson T, Lycke J. Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis. Mul-tiple Sclerosis Journal 2017; 23(1): 62-71
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IV. Novakova L, Zetterberg H, Sundström P, Axelsson M, Khademi M, Gunnars-son M, Malmeström C, Svenningsson A, Olsson T, Piehl F, Blennow K, Lycke J. Monitoring disease activity in multiple sclerosis using serum neurofilament light protein. Neurology 2017; 89(22): 2230-2237
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V. Novakova L, Axelsson M, Malmeström C, Imberg H, Elias O, Zetterberg H, Nerman O, Lycke J. Searching for neurodegeneration in multiple sclerosis at clinical onset: diagnostic value of biomarkers. Accepted for publication in PLOS ONE
Date of Defence: 2018-04-13
Disputation: Fredagen den 13 april 2018, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: biomarkers
multiple sclerosis
neurodegeneration
inflammation
treatment
Abstract: The pathophysiology of multiple sclerosis (MS) is complex with the presence of inflammation and neurodegeneration in all stages of the disease. The disease course, treatment response and outcome are highly variable in MS. There is a need for reliable biomarkers reflecting different parts of the pathophysiology of MS that may improve the decision-making between various treatment options. The aim of the thesis was to investigate the influence of different therapies on biomarker levels in cerebrosp... more
ISBN: 978-91-629-0438-8 (PRINT)
978-91-629-0439-5 (PDF)
URI: http://hdl.handle.net/2077/54957
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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