Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi: Recent submissions
Now showing items 1-20 of 488
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The alpha 7 nicotinic acetylcholine receptor in cardiovascular disease
(2024-09-26)The alpha 7 acetylcholine nicotinic receptors (α7nAChRs) are expressed on human leukocytes and regulate inflammation. Consequently, the α7nAChRs are potential pharmacological targets for several inflammatory diseases. ... -
Social and motor coordination: methods development and applications in ESSENCE
(2024-09-24)This thesis aimed to develop and apply methods for evaluating social and motor coordination, domains that often are challenged in individuals with neurodevelopmental/neuropsychiatric disorders (NDDs), also referred within ... -
Survival of patients with glioblastoma - advancements in the past two decades
(2024-09-24)Background: Glioblastoma is the most common and most aggressive form of primary malignant brain tumors in adults. The prognosis is generally poor, with a median survival of around 15-16 months, even with aggressive multimodal ... -
Thoracic Mobility in Cystic Fibrosis Care
(2024-08-19)Introduction: Cystic fibrosis (CF) is an incurable and highly life-limiting hereditary disease. However, due to significant medical advancements over recent decades, life expectancy has risen to close to 50 years. As such, ... -
Physical Activity Before and After Stroke - Examining Stroke lncidence and Outcomes
(2024-05-24)Background: Stroke is a leading cause of death and disability worldwide. A physically active lifestyle may prevent stroke and decrease the consequences of a stroke. Physical activity is also an important component in ... -
Ge de ohörda rösterna upprättelse - framsteg och utmaningar vid involvering av sköra äldre personer i forskning om åldrande och hälsa
(2024-05-16)Introduktion: I Sverige och globalt har vi en demografisk utveckling med en allt större del åldrad befolkning. Forskning om åldrande och hälsa har därför en allt viktigare roll i samhället. Samtidigt är det just nu en ... -
Meningiomas - consequences of incidental detection and novel classification
(2024-05-06)Aim Meningiomas are often benign, slow-growing tumors found in older individuals. This thesis aimed to examine the occurrence of incidental meningioma, the surgical and quality of life outcomes after surgery and to evaluate ... -
Visual function and functional vision – ophthalmological perspectives on a normal population
(2024-05-03)Aim: The aim was to investigate visual function and functional vision in 70-year-olds in Gothenburg Sweden. Methods: A group 1203 randomized 70-year-olds completed questionnaires on somatic, social health, and well-being. ... -
Cholinergic modulation of dopamine-related effects of ethanol in the rat
(2024-04-25)Alcohol use disorder is associated with serious medical consequences leading to preterm death. Alcohol activates the brain reward system, leading to an increase of extracellular dopamine (DA) levels in the nucleus accumbens ... -
Psychological outcomes during rehabilitation after ACL reconstruction - and implications for second ACL injury
(2024-04-24)An anterior cruciate ligament (ACL) injury is a common knee joint injury. An ACL injury is typically managed through surgical reconstruction of the ligament, followed by rehabilitation. For patients treated with ... -
Predictors of severe kidney disease in long-term lithium treatment
(2024-04-22)The thesis aims to advance the understanding of severe chronic kidney disease in lithium-treated patients through four observational studies in which subjects were recruited from the Sahlgrenska University Hospital laboratory ... -
Physiotherapist as primary assessor of knee osteoarthritis in primary care - Evaluation of patients’ self-assessment, preferences, quality of life, and health economy
(2024-03-27)Aim: The purposes with this thesis was to evaluate the feasibility of 30-second chair stand test as a self-test, and to investigate the effects of direct access to physiotherapist on costs and health in people with knee ... -
lnduction Therapies in Multiple Sclerosis - Clinical and immunological follow-up
(2024-03-21)Multiple sclerosis (MS) is a chronic disease that damages the central nervous system. Its pathophysiology is complex, and consists of inflammation and degeneration from the disease onset. The treatment of MS has continuously ... -
Polycystic ovary syndrome in women with severe obesity - effects of a 12-month weight loss intervention
(2024-03-19)Background: Polycystic ovary syndrome (PCOS) affects one out of eight women and is associated with reproductive, metabolic, and psychiatric features. There is a strong association with obesity but studies on PCOS in women ... -
Health conditions, functioning and social outcomes in adults with cerebral palsy
(2024-02-21)Background: A majority of individuals with cerebral palsy (CP) are adults, and yet healthcare and research are focused on children. In comparison to the consequences in childhood, little is known about the long-term ... -
A treatment seeking population with Gambling Disorder - Internet treatment, severity and gender
(2024-02-21)Gambling is a common pastime all over the world, but can become harmful in excess and can even develop into an addictive behavior, a Gambling Disorder (GD). The aim of this thesis was to contribute to the clinical understanding ... -
Regulation of amyloid beta generation and its involvement in synaptic function: studies in human iPSC-derived cortical neurons
(2024-02-21)Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and exerts a profound societal and economic impact. Clinically characterized by a gradual loss of memory, cognitive and ... -
Labile glutamate synaptic transmission onto CA1 hippocampal pyramidal neurons: regional, functional and developmental diversity
(2024-02-14)A single neuron in the brain receives tens of thousands of glutamate synapses from other neurons, and these synapses can differ in their properties depending on their role in the neural circuit, during brain development ... -
Outcome after treatment of cerebral aneurysms
(2024-02-08)A cerebral aneurysm is a saccular or tubular-like deformity of the arterial vessel wall which is usually thinner. The rupture of a cerebral aneurysm is associated with a high morbidity and mortality by causing an aneurysmal ... -
Speech production and literacy in students with intellectual disabilities and communication difficulties
(2024-02-07)Many individuals with intellectual disabilities have difficulties with spoken communication and literacy learning leading to vulnerability. It has been suggested that interventions to promote reading in this group not only ...