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Characterizing the role of long non coding RNAs epigenetic regulators in disease model

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Title: Characterizing the role of long non coding RNAs epigenetic regulators in disease model
Authors: Mishra, Kankadeb
Issue Date: 17-Nov-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology
Parts of work: I. H3K4me2 and WDR5 enriched chromatin interacting long non-coding RNAs maintain transcriptionally competent chromatin at divergent transcriptional units. Mishra K, Subhash S, Akhade VS, Kanduri M, Mondal T and Kanduri C (manuscript).

II. The Risk-Associated Long Noncoding RNA NBAT-1 Controls Neuroblastoma Progression by Regulating Cell Proliferation and Neuronal Differentiation. Pandey GK, Mitra S, Subhash S, Hertwig F, Kanduri M, Mishra K, Fransson S, Ganeshram A, Mondal T, Bandaru S, Ostensson M, Akyürek LM, Abrahamsson J, Pfeifer S, Larsson E, Shi L, Peng Z, Fischer M, Martinsson T, Hedborg F, Kogner P, Kanduri C. Cancer Cell, 2014 Nov 10; 26(5):722-37.

III. The KCNQ1OT1 imprinting control region and non-coding RNA: new properties derived from the study of Beckwith–Wiedemann syndrome and Silver–Russell syndrome cases. Chiesa N, De Crescenzo A, Mishra K, et al. Human Molecular Genetics. 2012; 21(1):10-25.

Date of Defence: 2017-12-07
Disputation: Torsdagen den 7 december 2017, kl. 13.00, Hörsal Ragnar Sandberg, Medicinaregatan 7A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Long non-coding RNA
Active Chromatin
Genomic Imprinting
Beckwith-Wiedemann Syndrome
Abstract: Long non-coding RNAs (lncRNAs) are a class of biological molecules which are transcribed from DNA but are not translated into any protein. LncRNAs have been identified as critical players in gene regulation. Misregulation of lncRNAs has been considered as one of the underlying causes for cancer pathogenesis and in other human diseases. In the current thesis, I have addressed the epigenetic roles of lncRNAs in regulating gene expression in cell line based and disease model systems. We investigat... more
ISBN: 978-91-629-0368-8 (Print)
978-91-629-0369-5 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



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