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Piperaquine and Metabolites - Bioanalysis and Pharmacokinetics


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Title: Piperaquine and Metabolites - Bioanalysis and Pharmacokinetics
Authors: Aziz, Mohd Yusmaidie
E-mail: mohd.yusmaidie@gu.se
Issue Date: 28-Sep-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Pharmacology
Parts of work: 1. Aziz MY, Hoffmann K-J, Ashton M. LC–MS/MS quantitation of antimalarial drug piperaquine and metabolites in human plasma. Journal of Chromatography B. 2017;1063:253-8.
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2. Mohd Yusmaidie Aziz, Kurt-Jürgen Hoffmann and Michael Ashton. Inhibition of CYP3A by antimalarial piperaquine and its metabolites in human liver microsomes with IVIV extrapolation. Submitted

3. Mohd Yusmaidie Aziz, Kurt-Jürgen Hoffmann and Michael Ashton. Plasma protein binding of piperaquine and its metabolites: Binding to human plasma, serum albumin and α1-acid glycoprotein. Manuscript

4. Mohd Yusmaidie Aziz, Trinh Ngoc Hai, Emma Johansson, Le Minh Dao, Pham Thi Thinh and Michael Ashton. Dose- and time-independent pharmacokinetics of piperaquine and its metabolites in healthy male Vietnamese subjects after four escalating oral doses separated by one month. Manuscript
Date of Defence: 2017-10-23
Disputation: Måndagen den 23 Oktober 2017, 13.00, Åke Göransson, Medicinaregatan 11, Göteborg
Degree: Doctor of Philosophy (Pharmaceutical science)
Publication type: Doctoral thesis
Keywords: Bioanalysis
Pharmacokinetics
Piperaquine
Malaria
Abstract: Antimalarial piperaquine (PQ) is currently used as a partner drug with dihydroartemisinin (DHA), exhibiting high cure rates (>95%) for P. falciparum. Despite its raising usage worldwide with DHA, PQ is synthetically developed outside of big pharma pipelines. Thus, there is potentially some scientific gap in the information regarding disposition of the drug not being systematically established. This thesis comprised studies on bioanalysis- (Paper I), CYP3A4/5 inhibitory potential- (Paper II), pro... more
ISBN: 978-91-629-0253-0 (print)
978-91-629-0253-7 (pdf)
URI: http://hdl.handle.net/2077/52861
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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