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Genomic instability and genetic heterogeneity in neuroblastoma tumours

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Title: Genomic instability and genetic heterogeneity in neuroblastoma tumours
Authors: Javanmardi, Niloufar
Issue Date: 3-Nov-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Pathology
Parts of work: I . Schleiermacher G, Javanmardi N, Bernard V, Leroy Q, Cappo J, RioFrio T, Pierron G, Lapouble E, Combaret V, Speleman F, de Wild B, Djos A, Ora I, Hedborg F, Träger C, Holmqvist BM, Abrahamsson J, Peuchmaur M, Michon J, Janoueix-Lerosey I, Kogner P, Delattre O, Martinsson T; Emergence of new ALK mutations at relapse of neuroblastoma. J Clin Oncol. 2014 Sep 1;32(25):2727-34

I I . Javanmardi N, Fransson S, Djos A, Umapathy G, Östensson M, Milosevic J, Kogner P, Hallberg B, Martinsson T, and Palmer RH; The 2p cassette gain in neuroblastoma tumours, A potent combination of ALK, MYCN and the ALK ligand ALKAL2 (FAM150B/AUGa). 2017, Manuscript

I I I . Javanmardi N, Fransson S, Djos A, Sjöberg RM, Nilsson S, Lorentzen E, Truvé K, Kogner P, Martinsson T; Low frequency ALK hotspots mutations in Neuroblastoma tumours detected by ultra deep sequencing: Implications for ALK inhibitor treatment. 2017, Manuscript

IV. Javanmardi N, Fransson S, Djos A, Sjöberg RM, Östensson M, Bergerall A, Carén H, Beiske K, Palmer RH, Hallberg B, Noguera R, Kogner P and Martinsson T; Chromosome 11 in high-risk neuroblastoma tumours; A loss and gain pattern indicative of both tumour suppressor and oncogene activity. 2017, Manuscript
Date of Defence: 2017-11-23
Disputation: Torsdagen den 23 november 2017, kl. 9.00, Hörsal Ivan Östholm, Medicinaregatan 13, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Neuroblastoma tumour
deep sequencing
tumour supressor gene
Abstract: Javanmardi, N., 2017, Genomic instability and genetic heterogeneity in neuroblastoma Department of Pathology and Clinical Genetics, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Sweden Neuroblastoma (NB), a tumour of the sympathetic nervous system and the most common malignant disease of early childhood, is responsible for 9% of paediatric cancer related deaths. Aggressive NB still constitutes a major clinical problem with survival rates of about 35%. It is the... more
ISBN: 978-91-629-0336-7 (print)
978-91-629-0337-4 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



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