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Stem cells in the adult heart - 3D culture, isolation of side population cells and search for a stem cell niche


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Title: Stem cells in the adult heart - 3D culture, isolation of side population cells and search for a stem cell niche
Authors: Vukusic, Kristina
E-mail: kristina.vukusic@gu.se
Issue Date: 26-Oct-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Clinical Chemistry and Transfusion Medicine
Parts of work: I. High density sphere culture of adult cardiac cells increases the levels of cardiac and progenitor markers and shows signs of vasculogenesis. Vukusic K, Jonsson M, Brantsing C, Dellgren G, Jeppsson A, Lindahl A. and Asp J. BioMed Research International 2013; 696837
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II. Left atrium of the human adult heart contains a population of side population cells. Sandstedt J, Jonsson M, Kajic K, Sandstedt M, Lindahl A, Dellgren G, Jeppsson A and Asp J. Basic research in cardiology 2012 Mar; 107(2):255
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III. Physical exercise affects slow cycling cells in the rat heart and reveals a new potential niche area in the atrioventricular junction. Vukusic K, Asp J, Henriksson HB, Brisby H, Lindahl A and Sandstedt J. Journal of Molecular Histology 2015 Oct; 46(4-5):387-98
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IV. Atrioventricular junction of the human adult heart harbours stem cells, different stages of cardiomyocytes and shows signs of hypoxia, proliferation and migration. Vukusic K, Jansson M, Jonsson M, Sandstedt M, Oldfors A, Jeppsson A, Dellgren G. Lindahl A and Sandstedt J. in Manuscript
Date of Defence: 2017-11-17
Disputation: Fredagen den 17 november 2017, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Heart
cardiac stem cells
Stem cell niche
Atrioventricular junction
Side population
3D culture
Abstract: Cardiac tissue shows a poor regenerative capacity. From 2003 reports, mostly based on animal models, have showed existence of stem cells also in the heart. Using 14C measurements, a slow but steady turnover of the cardiac cells was shown in humans, around 1%/year. As a source for this regeneration endogenous stem cells have been suggested. The aim of this thesis was to identify, isolate and characterize cardiac stem cells and to find their niche. Therefore, in Study I a new “High Density S... more
ISBN: 978-91-629-0231-5 (PRINT)
978-91-629-0230-8 (TRYCK)
URI: http://hdl.handle.net/2077/52854
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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