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Dental acrylates and methacrylates - Interactions with the immune system


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Title: Dental acrylates and methacrylates - Interactions with the immune system
Authors: Alizadehgharib, Sara
E-mail: Sara.Alizadehgharib@gu.se
Issue Date: 10-Oct-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Odontology. Department of Oral Microbiology
Parts of work: I. Alizadehgharib S, Östberg AK, Larsson L and Dahlgren U. The immunomodulatory properties of 2-hydroxyethyl methacrylate are mediated by the NLRP3 inflammasome. Submitted for publication.

II. Alizadehgharib S, Östberg AK and Dahlgren U. Triethylene glycol dimethacrylate – adjuvant properties and effect on cytokine production. Submitted for publication.

III. Östberg AK, Alizadehgharib S and Dahlgren U. Sublingual administration of 2- hydroxyethyl methacrylate enhances antibody responses to co-administered ovalbumin and Streptococcus mutans. Submitted for publication.

IV. Alizadehgharib S, Östberg AK and Dahlgren U. Effects of the methacrylate/acrylate monomers HEMA, TEGDMA, DEGDA and EMA on the immune system. Submitted for publication.

V. Basic A, Alizadehgharib S, Dahlén G and Dahlgren U. Hydrogen Sulfide exposure induces NLRP3 inflammasome-dependent IL-1β and IL-18 secretion in human mononuclear leukocytes in vitro. Clinical and Experimental Dental Research 2017. 3:115-120.
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Date of Defence: 2017-10-27
Disputation: Fredagen den 27 oktober 2017, kl. 13.00, Föreläsningssal 3, Odontologen, Medicinaregatan 12D, Göteborg
Degree: Doctor of Philosophy (Odontology)
Publication type: Doctoral thesis
Keywords: Acrylates
Methacrylates
Antibodies
NLRP3 inflammasome
Cytokines
Mice
Hydrogen sulfide
Abstract: Professionals working in dentistry have reported adverse effects, such as allergic contact dermatitis due to exposure to different methacrylates/acrylates. Leakage of such monomers from dental fillings due to incomplete curing is also common. Monomers are released into the oral cavity and some may also diffuse through the dentin and reach the dental pulp. In the tissue, monomers will come in contact with different cells of the immune system. At present, there is a lack of knowledge of the ef... more
ISBN: ISBN 978-91-629-0245-2 (PDF)
ISBN 978-91-629-0244-5 (Print)
URI: http://hdl.handle.net/2077/52846
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för odontologi

 

 

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