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Natural killer T (NKT) lymphocytes regulate of intestinal tumor immunity


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/52418

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Title: Natural killer T (NKT) lymphocytes regulate of intestinal tumor immunity
Authors: Wang, Ying
E-mail: ying.wang@gu.se
Issue Date: 1-Sep-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Microbiology and Immunology
Parts of work: I. Wang Y, Sedimbi S, Löfbom L, Singh A K, Porcelli S A, and Cardell S L. Unique invariant natural killer T cells promote intestinal polyps by suppressing TH1 immunity and promoting regulatory T cells. Mucosal Immunology.
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II. Wang Y, Sedimbi S, Löfbom L, Porcelli S A, and Cardell S L. Modulation of intestinal polyp development by natural killer (NK) T cell directed immunotherapy. Manuscript.

III. Wang Y, Löfbom L, Porcelli S A, Yagita H, and Cardell S L. Natural killer T cell agonist and PD-1 blockade cooperate to reduce intestinal tumor development. Manuscript.
Date of Defence: 2017-09-22
Disputation: Fredagen den 22 september 2017, kl 9.00, Hälsovetarbacken, rum 2118, Hus 2, Arvid Wallgrens backe, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: NKT lymphocyte
intestinal tumor
CD1d
colrectal cancer
immunoregulation
α-gagactosylceramide
Abstract: CD1d-restricted natural killer T (NKT) lymphocytes are known as potent early regulatory cells of immune responses, acting as a bridge between innate and adaptive immunity. While invariant NKT (iNKT) cells have a protective role in many tumor models, their ability to promote intestinal inflammation, known to enhance intestinal cancer, raised the question if they would be protective in intestinal tumor development. In this thesis we aimed to define the regulatory role of iNKT lymphocytes in the im... more
ISBN: 978-91-629-0273-5 (PDF)
978-91-629-0272-8 (PRINT)
URI: http://hdl.handle.net/2077/52418
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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