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The role of fusion oncogenes and cancer stem cells in myxoid liposarcoma

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Title: The role of fusion oncogenes and cancer stem cells in myxoid liposarcoma
Authors: Dolatabadi, Soheila
Issue Date: 7-Aug-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Pathology
Parts of work: I. Ståhlberg, A., et al., Normal and Functional TP53 in Genetically Stable Myxoid/Round Cell Liposarcoma. PLoS ONE, 2014. 9(11)

II. Åman, P., et al., Regulatory mechanisms, expression levels and proliferation effects of the FUS-DDIT3 fusion oncogene in liposarcoma. J Pathol, 2016. 238(5): p. 689-99.

III. Dolatabadi, S., et al., Cell cycle and cell size dependent gene expression reveals distinct subpopulations at single-cell level. Frontiers in Genetics, 2017. 8(1).

IV. Svec, D., et al., Identification of inhibitors regulating cell proliferation and FUS-DDIT3 expression in myxoid liposarcoma using combined DNA, mRNA and protein analyses. Manuscript.

V. Dolatabadi, S., et al., JAK-STAT signalling controls cancer stem cell properties in myxoid liposarcoma. Manuscript.
Date of Defence: 2017-09-29
Disputation: Fredagen den 29 september 2017, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: FUS
myxoid liposarcoma
cancer stem cells
Abstract: Myxoid liposarcoma (MLS) is characterised by the FUS-DDIT3, or the less common EWSR1-DDIT3 fusion oncogene and is the second most common type of liposarcoma. The fusion oncogenes encode chimeric transcription factors that are causal factors in tumourigenesis however, their functions are poorly known. Notwithstanding continuous progress in treating MLS patients, existing therapies suffer from a major flaw as they do not target the cancer stem cells (CSCs). Unique features of CSCs include self-ren... more
ISBN: 978-91-629-0199-8 (Print)
978-91-629-0200-1 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



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