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Bone Morphogenetic Protein 4 regulates white, beige and brown adipose tissue

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Title: Bone Morphogenetic Protein 4 regulates white, beige and brown adipose tissue
Authors: Hoffmann, Jenny
Issue Date: 10-May-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: I. Gustafson B, Hammarstedt A, Hedjazifar S, Hoffmann JM, Svensson PA, Grimsby J, Rondinone C and Smith U. BMP4 and BMP antagonists regulate human white and beige adipogenesis. Diabetes 2015 May; 64 (5):1670-81.

II. Hoffmann JM, Grünberg JR, Church C, Elias I, Palsdottir V, Jansson J-O, Bosch F, Hammarstedt A, Hedjazifar S and Smith U. BMP4 gene therapy in mature mice reduces BAT activation but protects from obesity by browning subcutaneous adipose tissue. Manuscript under revision.

III. Hoffmann JM, Hammarstedt A, Grünberg JR, Elias I, Palsdottir V, Bosch F, Hedjazifar S and Smith U. BMP4 gene therapy improves insulin resistance in obese mice without effects on adipose tissue browning or body weight. Manuscript.
Date of Defence: 2017-06-09
Disputation: Fredagen den 9 juni 2017, kl. 13.00, Hjärtats Aula, Vita Stråket 12, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Obesity
insulin sensitivity
Abstract: Obesity and its associated complications, including Type 2 diabetes, are increasing at an epidemic rate globally. Adipose tissue exerts different functions and is central in energy homeostasis, and it consists of white, beige or brown adipocytes. White adipocytes (in white adipose tissue, WAT) store and release lipids while brown adipocytes (in brown adipose tissue, BAT), oxidize lipids and generate heat. Beige adipocytes reside in WAT, appear white but can oxidize lipids upon stimulation (brown... more
ISBN: 978-91-629-0147-9 (PRINT)
978-1-629-0148-6 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin



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