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Interrogation of Biological Samples by ToF-SIMS using New Primary Ion Beams and Sample Preparation Methods


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/50294

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gupea_2077_50294_1.pdfThesis introduction + summary of papers25063KbAdobe PDF
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Title: Interrogation of Biological Samples by ToF-SIMS using New Primary Ion Beams and Sample Preparation Methods
Other Titles: Interrogation of Biological Samples by ToF-SIMS
Authors: Angerer, Tina
E-mail: tina.angerer@chem.gu.se
Tinabernadette.angerer@gmail.com
Issue Date: 12-Jan-2017
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: 3D Imaging of TiO2 nanoparticle accumulation in Tetrahymena pyriformis.T. B. Angerer, J. S. Fletcher, Surf. Interface Anal. 46, 198-203 (2014).
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High energy gas cluster ions for organic and biological analysis by time-of-flight secondary ion mass spectrometry. T. B. Angerer, P. Blenkinsopp, J. S. Fletcher. Int. J. Mass. Spectrom. 377, 591-598 (2015).
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Measuring Compositions in Organic Depth Profiling: Results from a VAMAS Interlaboratory Study. Alexander G. Shard, Rasmus Havelund, Steve J. Spencer, Ian S. Gilmore, Morgan R. Alexander, Tina B. Angerer, Satoka Aoyagi, Jean-Paul Barnes, Anass Benayad, Andrzej Bernasik, Giacomo Ceccone, Jonathan D. P. Counsell, Christopher Deeks, John S. Fletcher, Daniel J. Graham, Christian Heuser, Tae Geol Lee, Camille Marie, Mateusz M. Marzec, Gautam Mishra, Derk Rading, Olivier Renault, David J. Scurr, Hyun Kyong Shon, Valentina Spampinato, Hua Tian, Fuyi Wang, Nicholas Winograd, Kui Wu, Andreas Wucher, Yufan Zhou, and Zihua Zhu. J., Phys. Chem. B 119, 10784-10797 (2015).
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Improved Molecular Imaging in Rodent Brain with Time-of-Flight-Secondary Ion Mass Spectrometry Using Gas Cluster Ion Beams and Reactive Vapor Exposure. T. B. Angerer, M. D. Pour, P. Malmberg, J. S. Fletcher, Anal. Chem. 87, 4305-4313 (2015).
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Optimizing sample preparation for anatomical determination in the hippocampus of rodent brain by ToF-SIMS analysis. T. B. Angerer, A. S. Mohammadi, J. S. Fletcher, Biointerphases 11, 02A319 (2016).
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Lipid Heterogeneity Resulting from Fatty Acid Processing in the Human Breast Cancer Microenvironment Identified by GCIB-ToF-SIMS Imaging. T. B. Angerer, Y. Magnusson, G. Landberg, J. S. Fletcher, Anal. Chem. 88, 11946-11954 (2016).
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Date of Defence: 2017-02-03
Disputation: Fredagen den 3 februari 2017 kl. 10.00 i sal KA, institutionen för kemi och molekylärbiologi, Kemigården 4, Göteborg
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: ToF-SIMS
time of flight secondary ion mass spectrometry
imaging mass spectrometry
gas cluster ion beam
GCIB
sample preparation
frozen hydrated
Tetrahymena
titanium dioxide
nanoparticles
Irganox
brain analysis
depth profiles
matrix effects
biological samples
lipids
fatty acids
breast cancer
cancer microenvironment
Abstract: Mass spectrometry is a very versatile and important technique in analytical chemistry. From atomic bombs to Alzheimer’s disease, after a century of improvements and developments there are now countless applications for mass spectrometry in research and industry. One important branch within the field is imaging mass spectrometry as it combines chemical and location specific information. Lipids, the main building blocks of cell membranes, are found in all living, cellular organisms. They are a d... more
ISBN: 978-91-629-0073-1
978-91-629-0074-8
URI: http://hdl.handle.net/2077/50294
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

 

 

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