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Adaptive immune maturation in relation to allergic disease and vaccine responses in children


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Title: Adaptive immune maturation in relation to allergic disease and vaccine responses in children
Authors: Strömbeck, Anna
E-mail: anna.strombeck@microbio.gu.se
Issue Date: 30-Jan-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Rheumatology and Inflammation Research
Parts of work: Strömbeck A et al. High proportions of FOXP3+CD25high T cells in neonates are positively associated with allergic sensitization later in childhood. Clinical & Experimental Allergy, 2014;44:940-52.
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Strömbeck A et al. Earlier infantile immune maturation is related to higher DTP-vaccine responses in children. Clinical & Translational Immunology. 2016 Mar 11;5(3):e65
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Strömbeck A et al. Delayed adaptive immunity is related to higher MMR vaccine-induced antibody titers in children. Clinical & Translational Immunology. 2016 Apr 29;5(4):e75
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Strömbeck A et al. Allergic disease in 8-year old children is preceded by delayed B-cell maturation. Submitted manuscript.
Date of Defence: 2017-02-16
Disputation: Torsdagen den 16 februari 2017, kl 9.00, Föreläsningssalen våning 3, Guldhedsgatan 10A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Adaptive immune maturation
children
allergic disease
farm
vaccine responses
prospective birth-cohort
multivariate factor analysis
Abstract: Adaptive immune maturation in children is likely the result of a complex interplay between both intrinsic and environmental factors, but surprisingly little is known about how early life immune maturation is related to immune responses and subsequent development of allergic disease. The aim of the FARMFLORA birth-cohort study, including farmers’ and non-farmers’ children, was to visualize longitudinal patterns of adaptive immune maturation in relation to allergic sensitization and disease, vacci... more
ISBN: 978-91-629-0067-0 PRINT
978-91-629-0068-7 PDF
URI: http://hdl.handle.net/2077/49485
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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