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Nicotine sensitization and the effects of extended withdrawal - behavioral, neurochemical and electrophysiological studies in the rat


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/48662

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Title: Nicotine sensitization and the effects of extended withdrawal - behavioral, neurochemical and electrophysiological studies in the rat
Authors: Morud Lekholm, Julia
E-mail: julia.morud@neuro.gu.se
Issue Date: 14-Dec-2016
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: 1. Morud J*, Adermark L*, Perez-Alcazar M, Ericson M, Söderpalm B, Nicotine produces chronic behavioral sensitization with changes in accumbal neurotransmission and increased sensitivity to re-exposure. Addiction Biology 2015; 21(2):397-406.
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2. Adermark L, Morud J, Lotfi A, Jonsson S, Söderpalm B, Ericson M. Age-contingent influence over accumbal neurotransmission and the locomotor stimulatory response to acute and repeated administration of nicotine in Wistar rats. Neuropharmacology 2015; 97:104-12
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3. Morud J, Strandberg J, Andrén A, Ericson M, Söderpalm B, Adermark L. Extended nicotine withdrawal induces spontaneous disinhibition and alters accumbal neurotransmission. Submitted 2016.
Date of Defence: 2017-01-27
Disputation: Fredagen den 27 januari 2017, kl 9.00, Hörsal Åke Göransson, Medicinaregatan 11, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Abstinence
Dopamine
Elevated plus-maze
GABA
Inhibitory control
Nicotine
Nucleus accumbens
Sensitization
Abstract: Tobacco use is one of the primary factors for global burden of disease and often results in life-long nicotine addiction, only a small percentage users are able to maintain cessation. The life-long addiction together with a high relapse risk might be connected to drug-induced altered neural circuits. However, there is still uncertainty concerning the mechanisms involved in the progressive changes of neuronal function induced by repeated nicotine exposure. The rewarding effects of nicotine have b... more
ISBN: 978-91-629-0029-8 (print)
978-91-629-0030-4 (pdf)
URI: http://hdl.handle.net/2077/48662
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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