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Herpes simplex virus type 1 infection in the central nervous system - Experimental and clinical studies


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Title: Herpes simplex virus type 1 infection in the central nervous system - Experimental and clinical studies
Authors: Eriksson, Charlotta
Issue Date: 17-Nov-2016
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Infectious Diseases
Parts of work: I. Jennische E, Eriksson CE, Lange S, Trybala E, Bergström T. The anterior commissure is a pathway for contralateral spread of herpes simplex virus type 1 after olfactory tract infection. J Neurovirol 2015; 21(2): 129-147.
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II. Eriksson CE, Studahl M, Bergström T. Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis. J Neuroimmunol 2016; 295-296: 130-138
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III. Eriksson CE, Agholme L, Trybala E, Nazir FH, Satir TM, Zetterberg H, Bergström T, Bergström P. Transient cytopathogenicity despite increasing infectivity of herpes simplex virus types 1 and 2 during neuronal differentiation. Manuscript

IV. Altgärde N, Eriksson C, Peerboom N, Phan-Xuan T, Moeller S, Schnabelrauch M, Svedhem S, Trybala E, Bergström T, Bally M. Mucin-like Region of Herpes Simplex Virus Type 1 Attachment Protein Glycoprotein C (gC) Modulates the Virus-Glycosaminoglycan Interaction. J Biol Chem 2015; 290(35): 21473-21485
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Date of Defence: 2016-12-16
Disputation: Fredagen den 16 december 2016, kl. 09.00, Mikrobiologens föreläsningssal, vån 3, Guldhedsgatan 10A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: herpes simplex virus
herpes simplex encephalitis
central nervous system infection
complement system
aquaporin 9
glycoprotein C
differentiating neuronal cells
mucin-like region
Abstract: Alphaherpesvirus infections in the central nervous system (CNS) are rare but severe, and many patients show remaining neurological sequelae. While antiviral treatment has reduced the mortality, morbidity has not been diminished to the same degree, and the immune system activation might contribute to the pathogenesis. Clinical symptoms have often been in focus in previous studies of such infections, while the entry and spread of viral agents is less thoroughly elucidated. Therefore, the aim of th... more
ISBN: 978-91-628-9881-6 (Print)
978-91-628-9880-9 (PDF)
URI: http://hdl.handle.net/2077/47412
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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