GUPEA >
Sahlgrenska Academy / Sahlgrenska akademin >
Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi >
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi >

Studies on new pharmacological treatments for alcohol dependence - and the importance of objective markers of alcohol consumption


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/42349

Files in This Item:

File Description SizeFormat
gupea_2077_42349_4.pdfAbstract148KbAdobe PDF
View/Open
gupea_2077_42349_5.pdfthesis frame1476KbAdobe PDF
View/Open
Title: Studies on new pharmacological treatments for alcohol dependence - and the importance of objective markers of alcohol consumption
Authors: de Bejczy, Andrea
E-mail: andrea.debejczy@neuro.gu.se
Issue Date: 26-May-2016
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: I. The Effects of Mirtazapine Versus Placebo on Alcohol Consumption in Male High Consumers of Alcohol; A Randomized, Controlled Trial. Andrea de Bejczy, MD and Bo Söderpalm, MD, PhD. Journal of Clinical Psychopharmacology, Vol. 35, No.1, pp 43-50, February 2015
VIEW ARTICLE


II. Efficacy and Safety of the Glycine Transporter-1 Inhibitor Org 25935 for the Prevention of Relapse in Alcohol-Dependent Patients: A Randomized, Double-Blind, Placebo-Controlled Trial. Andrea de Bejczy, Kari R. Nations, Armin Szegedi, Joep Schoemaker, Frank Ruwe and Bo Söderpalm. Alcoholism: Clinical and Experimental Research, Vol.38, No.9, pp. 2427-2435, September 2014
VIEW ARTICLE


III. Varenicline for treatment of alcohol dependence: a randomized, placebo-controlled trial. Andrea de Bejczy*, MD, Elin Löf*, PhD, Lisa Walther, MD, Joar Guterstam, MD, Anders Hammarberg, PhD, Gulber Asanovska, MD, Johan Franck, prof., Anders Isaksson, associate prof., and Bo Söderpalm, prof. *shared first author Alcoholism: Clinical and Experimental Research, Vol.39, No.11, pp. 2189-2199, November 2015
VIEW ARTICLE


IV. Phosphatidylethanol is Superior to Carbohydrate-Deficient Transferrin and γ-Glutamyltransferase as an Alcohol Marker and is a Reliable Estimate of Alcohol Consumption Level. Lisa Walther, Andrea de Bejczy, Elin Löf, Therese Hansson, Anders Andersson, Joar Guterstam, Anders Hammarberg, Gulber Asanovska, Johan Franck, Bo Söderpalm and Anders Isaksson. Alcoholism: Clinical and Experimental Research, Vol.39, No.11, pp. 2200-2208, November 2015
VIEW ARTICLE

Date of Defence: 2016-06-17
Disputation: Fredagen den 17 juni 2016, kl 13.00, hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: alcohol dependence
mirtazapine
varenicline
org 25935
alcohol markers
phosphatidylethanol
randomized controlled clinical trials (RCT)
treatment
glycine transporter inhibitor
nAChR
Abstract: This thesis will guide you through three randomized controlled trials (RCT) on three pharmacotherapies for alcohol dependence; the antidepressant drug mirtazapine, the smoking cessation drug varenicline and the glycine-uptake inhibitor Org 25935. The mirtazapine study was an investigator initiated single-center harm-reduction study with alcohol consumption measured by self-report in a diary as main outcome. The results indicated that mirtazapine reduced alcohol consumption in males with heredity... more
ISBN: 978-91-628-9788-8 (printed)
978-91-628-9789-5 (e-publication)
URI: http://hdl.handle.net/2077/42349
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

© Göteborgs universitet 2011