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Extracellular Vesicles and RNA interference in tumors


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/42338

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Title: Extracellular Vesicles and RNA interference in tumors
Authors: Lunavat, Taral
E-mail: taral.lunavat@gu.se
Issue Date: 18-May-2016
University: University of Gothenburg. Sahlgrenska Academy
Institution: Inst of Medicine. Department of Internal Medicine and Clinical Nutrition
Parts of work: I. Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells--Evidence of unique microRNA cargos. Lunavat TR, Cheng L, Kim DK, Bhadury J, Jang SC, Lässer C, Sharples RA, López MD, Nilsson J, Gho YS, Hill AF, Lötvall J. RNA Biol. 2015;12(8):810-23.
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II. BRAF-inhibition alters melanoma vesicular secretome microRNA cargo. Taral Lunavat, Lesley Cheng, Berglind Einarsdottir, Roger Olofsson Bagge, Robin Sharples, Cecilia Lässer, Yong Song Gho, Andrew Hill, Jonas A. Nilsson, Jan Lötvall. Manuscript

III. siRNA Delivery by Exosome-Mimetic Nanovesicles – Implications for Targeting c-Myc in Cancer. Taral R Lunavat*, Su Chul Jang*, Lisa Nilsson, Hyun Taek Park, Gabriella Repiska, Cecilia Lässer, Jonas Nilsson, Yong Song Gho,* and Jan Lötvall*. Submitted
Date of Defence: 2016-06-10
Disputation: Fredag den 10 juni 2016, kl 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Melanoma
Therapeutics
Exosome-mimetic nanovesicles
Apoptotic bodies
Microvesicles
Exosomes
Abstract: Extracellular vesicles (EVs) including apoptotic bodies (ABs), microvesicles (MVs), exosomes (EXOs) and cell derived artificial nanovesicles (NVs) are important mediators of cell-to-cell communication, in part by transferring bioactive molecules such as DNA, mRNA, miRNA, siRNA, proteins, and lipids. These EVs are released by many cell types, including melanoma cells, and are found in many body fluids. EVs derived from various cell types differ in their molecular composition making them as import... more
ISBN: 978-91-628-9805-2 (pdf)
978-91-628-9804-5 (Print)
URI: http://hdl.handle.net/2077/42338
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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