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http://hdl.handle.net/2077/42338
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File | Description | Size | Format | |
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gupea_2077_42338_1.pdf | Thesis frame | 1784Kb | Adobe PDF | ![]() View/Open |
gupea_2077_42338_2.pdf | Abstract | 137Kb | Adobe PDF | ![]() View/Open |
Title: | Extracellular Vesicles and RNA interference in tumors |
Authors: | Lunavat, Taral |
E-mail: | taral.lunavat@gu.se |
Issue Date: | 18-May-2016 |
University: | University of Gothenburg. Sahlgrenska Academy |
Institution: | Inst of Medicine. Department of Internal Medicine and Clinical Nutrition |
Parts of work: | I. Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells--Evidence of unique microRNA cargos. Lunavat TR, Cheng L, Kim DK, Bhadury J, Jang SC, Lässer C, Sharples RA, López MD, Nilsson J, Gho YS, Hill AF, Lötvall J.
RNA Biol. 2015;12(8):810-23. VIEW ARTICLE II. BRAF-inhibition alters melanoma vesicular secretome microRNA cargo. Taral Lunavat, Lesley Cheng, Berglind Einarsdottir, Roger Olofsson Bagge, Robin Sharples, Cecilia Lässer, Yong Song Gho, Andrew Hill, Jonas A. Nilsson, Jan Lötvall. Manuscript III. siRNA Delivery by Exosome-Mimetic Nanovesicles – Implications for Targeting c-Myc in Cancer. Taral R Lunavat*, Su Chul Jang*, Lisa Nilsson, Hyun Taek Park, Gabriella Repiska, Cecilia Lässer, Jonas Nilsson, Yong Song Gho,* and Jan Lötvall*. Submitted |
Date of Defence: | 2016-06-10 |
Disputation: | Fredag den 10 juni 2016, kl 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg |
Degree: | Doctor of Philosophy (Medicine) |
Publication type: | Doctoral thesis |
Keywords: | Melanoma Therapeutics Exosome-mimetic nanovesicles Apoptotic bodies Microvesicles Exosomes |
Abstract: | Extracellular vesicles (EVs) including apoptotic bodies (ABs), microvesicles (MVs), exosomes (EXOs) and cell derived artificial nanovesicles (NVs) are important mediators of cell-to-cell communication, in part by transferring bioactive molecules such as DNA, mRNA, miRNA, siRNA, proteins, and lipids. These EVs are released by many cell types, including melanoma cells, and are found in many body fluids. EVs derived from various cell types differ in their molecular composition making them as import... more |
ISBN: | 978-91-628-9805-2 (pdf) 978-91-628-9804-5 (Print) |
URI: | http://hdl.handle.net/2077/42338 |
Appears in Collections: | Doctoral Theses from Sahlgrenska Academy Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet Doctoral Theses / Doktorsavhandlingar Institutionen för medicin |