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Targeting Myc-driven tumours - BETing on ATR

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Title: Targeting Myc-driven tumours - BETing on ATR
Authors: Veppil Muralidharan, Somsundar
Issue Date: 17-Mar-2016
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Surgery
Parts of work: Bhadury J, Nilsson LM, Muralidharan SV, Green LC, Li Z, Gesner EM, Hansen HC, Keller UB, McLure KG, Nilsson JA. BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma. Proceedings of the National Academy of Sciences. 2014 Jul 1;111(26):E2721-30

II. Muralidharan SV, Bhadury J, Nilsson LM, Green LC, McLure KG, Nilsson JA. BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells. Oncogene. 2016 Jan 25

III.“Synergistic enhancement of apoptosis in melanoma by ATR & BET bromodomain inhibitors”. Somsundar Veppil Muralidharan, Berglind Einarsdottir, Mattias Lindberg, Joydeep Bhadury, Eric Campeau, Roger Olofsson Bagge, Ulrika Stierner, Lars Ny, Lisa M. Nilsson and Jonas A. Nilsson (MANUSCRIPT).
Date of Defence: 2016-04-08
Disputation: Fredagen den 8 april 2016, kl 9.00, hörsal Waldemar Sjölander, Medicinaregatan 7A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Abstract: Cancer arises from loss of function of tumour suppressors and/or gain of function mutations in proto-oncogenes that disrupt the delicate balance required for homeostatic cell division, resulting in uncontrolled cell proliferation. Oncogenic transformation of multifaceted proto-oncogene - transcription factor - MYC can give rise to cancers and it is found to be deregulated in more than 70% of the tumours. Targeting MYC directly or identifying the Achille’s heel of MYC-driven tumours is thus a pro... more
ISBN: 978-91-628-9750-5 (pdf)
978-91-628-9751-2 (print)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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