GUPEA >
Faculty of Science / Naturvetenskapliga fakulteten >
Department of Chemistry and Molecular Biology / Institutionen för kemi och molekylärbiologi (2012-) >
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi >

Cellular Responses to Arsenite and Cadmium - Mechanisms of Toxicity and Defense in Saccharomyces cerevisiae


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/41542

Files in This Item:

File Description SizeFormat
gupea_2077_41542_1.pdfThesis frame1274KbAdobe PDF
View/Open
gupea_2077_41542_2.pdfAbstract46KbAdobe PDF
View/Open
Title: Cellular Responses to Arsenite and Cadmium - Mechanisms of Toxicity and Defense in Saccharomyces cerevisiae
Authors: Jacobson, Therese
E-mail: therese.jacobson@hotmail.com
Issue Date: 12-May-2016
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: Michael Thorsen*, Therese Jacobson*, Riet Vooijs, Clara Navarrete, Tijs Bliek, Henk Schat, Markus J. Tamás *Equal contribution “Glutathione serves an extracellular defence function to decrease arsenite accumulation and toxicity in yeast” Molecular Microbiology 2012, 84(6), 1177–1188
VIEW ARTICLE


Soheil Rastgou Talemi, Therese Jacobson, Vijay Garla, Clara Navarrete, Annemarie Wagner, Markus J. Tamás, Jörg Schaber ”Mathematical modelling of arsenic transport, distribution and detoxification processes in yeast” Molecular Microbiology 2014, 92(6), 1343–1356
VIEW ARTICLE


Therese Jacobson*, Clara Navarrete*, Sandeep K. Sharma, Theodora C. Sideri, Sebastian Ibstedt, Smriti Priya, Chris M. Grant, Philipp Christen, Pierre Goloubinoff, Markus J. Tamás *Equal contribution “Arsenite interferes with protein folding and triggers formation of protein aggregates in yeast” Journal of Cell Science 2012, 125(21): 5073–5083
VIEW ARTICLE


Therese Jacobson, Robbe Thange, Arghavan Assouri, Markus J. Tamás “Cadmium causes misfolding and aggregation of cytosolic proteins in yeast” Manuscript.
Date of Defence: 2016-06-02
Disputation: Torsdagen den 2 juni 2016, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3.
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: arsenic
arsenite
cadmium
glutathione
extracellular defense
protein aggregation
chaperones
proteasome
Saccharomyces cerevisiae
Abstract: All biological systems have to cope with a wide range of metals that are present in the environment. Metals can be essential or beneficial for life, inert or non-essential and toxic, often depending on their chemical form and concentration. Most organisms have evolved defense mechanisms in order to deal with toxic metals. The toxic effect of a certain metal depends on cellular uptake, the mode of action inside the cell, on the efficacy of cellular defense systems, and on the intracellular locali... more
ISBN: 978-91-628-9741-3
URI: http://hdl.handle.net/2077/41542
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

 

 

© Göteborgs universitet 2011