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Herpes Simplex Virus 1 DNA replication and its role in recombination and transcription


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/40883

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Title: Herpes Simplex Virus 1 DNA replication and its role in recombination and transcription
Authors: Tang, Ka-Wei
E-mail: kawei.tang@gu.se
Issue Date: 17-Dec-2015
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology
Parts of work: I. Olsson M, Tang KW, Persson C, Wilhelmsson LM, Billeter M, Elias P. Stepwise evolution of the herpes simplex virus origin binding protein and origin of replication. J Biol Chem. 2009 Jun 12;284(24):16246-55.
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II. Tang KW, Norberg P, Holmudden M, Elias P, Liljeqvist JÅ. Rad51 and Rad52 are involved in homologous recombination of replicating herpes simplex virus DNA. PLoS One. 2014 Nov 3;9(11):e111584.
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III. Tang KW, Zhao ZY, Samuelsson T, Elias P. Replication-dependent expression of herpes simplex virus 1 late genes is controlled by P-TEFb and SIF. Manuscript
Date of Defence: 2016-01-22
Disputation: Fredagen den 22 januari 2016, kl. 13.00, Hörsal Arvid Carlsson, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Herpes Simplex Virus 1
DNA replication
DNA recombination
Transcription
Abstract: Herpes simplex virus 1 (HSV-1) is one of nine different herpesvirus infecting man. They are all capable of establishing a life-long latent state following the primary infection. HSV-1 as well as other herpesviruses may reactivate from the latent state and give rise to a productive infection with clinical symptoms or asymptomatic shedding. HSV-1 infections are primarily treated by targeting the viral DNA replication carried out by a molecular machinery, a replisome, encoded by the virus. Here... more
ISBN: 978-91-628-9636-2 (print)
978-91-628-9637-9 (e-publ)
URI: http://hdl.handle.net/2077/40883
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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