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Virus Attenuation by Genome-Wide Alterations of Genomic Signatures

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Title: Virus Attenuation by Genome-Wide Alterations of Genomic Signatures
Authors: Holmudden, Martin
Issue Date: 6-Jul-2015
Degree: Student essay
Keywords: genomic signatures
synthetic biology
Abstract: Despite enormous efforts in biomedical research there is still a shortage of safe and efficacious viral vaccines. To develop a new vaccine is also costly and time consuming. We propose a synthetic biology approach for making viruses less harmful by making many small modifications to their genetic sequences. We establish using computational methods that viruses have pervasive, species-specific genomic signatures, and that alteration of the genomic signature by systematic modifications to a vi... more
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