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Stress-induced cardiomyopathy - clinical and experimental studies


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Title: Stress-induced cardiomyopathy - clinical and experimental studies
Authors: Jonatan, Oras
E-mail: jonatan.oras@vgregion.se
Issue Date: 23-Oct-2015
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Anesthesiology & Intensive Care Medicine
Parts of work: I. Oras J et al. High-Sensitive Troponin T and N-Terminal Pro B-Type Natriuretic Peptide for Early Detection of Stress-Induced Cardiomyopathy in Patients with Subarachnoid Hemorrhage. Neurocrit Care. 2015 Oct;23(2):233-42.
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II. J. Oras et al. Elevated high-sensitive troponin T on admission is an indicator of poor long-term outcome in patients with subarachnoid haemorrhage: a prospective observational study. Submitted manuscript

III. B. Redfors, J. Oras et al. Cardioprotective effects of isoflurane in a rat model of stress-induced cardiomyopathy (takotsubo). Int J Cardiol 2014 Oct 20;176(3):815-21.
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IV. J. Oras, B. Redfors, A. Ali, H. Seeman-Lodding, E.Omerovic, S-E. Ricksten. Mechanisms of isoflurane-induced cardioprotection in an experimental model of stress-induced cardiomyopathy. Manuscript
Date of Defence: 2015-11-13
Disputation: Fredagen den 13 oktover 2015, kl 13.00, Hjärtats Aula, Sahlgrenska universitetssjukhuset, Vita Stråket 12, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Stress-induced cardiomyopathy
Subarachnoid hemorrhage
tako-tsubo
isoflurane
outcome
cerebral infarction
hsTnT
NTproBNP
proteomics
bioinformatics
Abstract: Background: Stress-induced cardiomyopathy (SIC) is an acute cardiac condition with akinesia in the left ventricle (LV) that can be severe. A stress-trigger, physical or emotional, is usually identified preceding onset of symptoms and catecholamine overstimulation is involved in the pathogenesis of SIC. The akinesia seen in SIC is reversible and the short term prognosis is therefore considered to be very good. However, recent data suggest that the long term prognosis is equivalent to patients suf... more
ISBN: 978-91-628-9615-7 (e-published)
978-91-628-9616-4 (printed)
URI: http://hdl.handle.net/2077/39562
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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