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Glycolytic oscillations in individual yeast cells


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Title: Glycolytic oscillations in individual yeast cells
Authors: Gustavsson, Anna-Karin
Issue Date: 7-Jan-2015
University: Göteborgs universitet. Naturvetenskapliga fakulteten
Institution: Department of Physics ; Institutionen för fysik
Parts of work: I. Gustavsson A.-K., van Niekerk D.D., Adiels C.B., du Preez F.B., Goksör M. Snoep J. Sustained glycolytic oscillations in individual isolated yeast cells. FEBS J. 2012;279(16):2837-2847.
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II. Gustavsson A.-K., Adiels C.B., Goksör, M. Induction of sustained glycolytic oscillations in single yeast cells using microfluidics and optical tweezers. Proc. SPIE 2012;8458:84580Y-1-84580Y-7.
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III. Gustavsson A.-K., van Niekerk D.D., Adiels C.B., Kooi B., Goksör M. Snoep J. et al. Allosteric regulation of phosphofructokinase controls the emergence of glycolytic oscillations in isolated yeast cells. FEBS J. 2014;281(12):2784-2793.
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IV. Gustavsson A.-K., Adiels C.B., Mehlig B., Goksör, M. Entrainment of heterogeneous metabolic oscillations in single cells. Submitted
Date of Defence: 2015-01-16
Disputation: Fredagen den 16 januari 2015, kl. 9.30, hörsal KA, Institutionen för kemi, Kemigården 4
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Optical manipulation
Microfluidics
Fluorescence microscopy
Single cell analysis
Saccharomyces cerevisiae
Glycolysis
Oscillations
NADH
Heterogeneity
Synchronization
Robustness
Universality
Abstract: Oscillations in the concentration of yeast glycolytic intermediates have been intensively studied since the 1950s, but these studies have so far been limited to observations of average oscillatory behavior in synchronized cultures. Hence, it has remained unknown whether the onset of oscillations is a collective property of the population which requires a high cell density, or if individual cells can oscillate also in isolation. To determine the mechanisms behind oscillations, cell-cell interacti... more
ISBN: 978-91-628-9228-9
978-91-628-9230-2
URI: http://hdl.handle.net/2077/37367
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för fysik

 

 

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