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Folates in the treatment of colorectal cancer


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Title: Folates in the treatment of colorectal cancer
Authors: Taflin, Helena
E-mail: helena.taflin@vgregion.se
Issue Date: 11-May-2015
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Surgery
Parts of work: I. Taflin H, Wettergren Y, Odin E, Carlsson G, Derwinger K. Gene polymorphisms MTHFRC677T and MTRA2756G as predictive factors in adjuvant chemotherapy for stage III colorectal cancer. Anticancer Res. 2011 Sep:31(9):3057-62.
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II. Taflin H, Wettergren Y, Odin E, Carlsson G, Derwinger K Folate Levels and Polymorphisms in the Genes MTHFR, MTR, and TS in Colorectal Cancer. Clin Med Insights Oncol. 2014 Feb:17(8):15-20.
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III. Taflin H, Wettergren Y, Odin E, Derwinger K Folate levels measured by LC-MS/MS in patients with colorectal cancer treated with different leucovorin dosages. Cancer Chemoth Pharma. 2014 Sep 20. Epub ahead of print

IV. Wettergren Y, Taflin H, Odin E, Kodeda K, Derwinger K A pharmacokinetic and pharmacodynamic investigation of Modufolin® compared to Isovorin® after single dose intravenous administration to patients with colon cancer: a randomized study. Cancer Chemoth Pharm. 2014 Oct. 24. Epub ahead of print
Date of Defence: 2014-12-05
Disputation: Fredag den 5 december 2014, kl 9.00, Östra sjukhusets Aula
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Folate
Colorectal cancer
leucovorin
modufolin
LC-MS/MS
polymorphisms
MTHFR
adjuvant chemotherapy
Abstract: ABSTRACT Folates in the Treatment of Colorectal Cancer Department of Surgery Institute of Clinical Sciences at Sahlgrenska Academy University of Gothenburg Helena Taflin Background: Colorectal cancer is one of the most common cancers in the world, and radical surgery with total removal of the tumour (RO-resection) is the single most important treatment. However, chemotherapy is recommended for patients with risk factors and patients with metastatic disease. 5-fluoruracil (5-FU) is the corner... more
ISBN: 978-91-628-9212-8
URI: http://hdl.handle.net/2077/36748
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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