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Regulation of metabolism and inflammation by two protein kinases - AMPK and STK25

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Title: Regulation of metabolism and inflammation by two protein kinases - AMPK and STK25
Authors: Cansby, Emmelie
Issue Date: 2-Jul-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: I. Nerstedt A, Johansson A, Andersson CX, Cansby E, Smith U, Mahlapuu M.AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).Diabetologia. 2010 Nov;53(11):2406-16.

II. Nerstedt A, Cansby E, Amrutkar M, Smith U, Mahlapuu M.Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes.Mol Cell Endocrinol. 2013 Aug 15;375(1-2):68-78.

III. Cansby E, Nerstedt A, Amrutkar M, Durán EN, Smith U, Mahlapuu M.Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained.Mol Cell Endocrinol. 2014 Jun 26. pii: S0303-7207(14)00197-X.

IV. Nerstedt A, Cansby E, Andersson CX, Laakso M, Stančáková A, Blüher M, Smith U, Mahlapuu M.Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle.Diabetologia. 2012 Jun;55(6):1797-807.

V. Cansby E, Amrutkar M, Mannerås Holm L, Nerstedt A, Reyahi A, Stenfeldt E, Borén J, Carlsson P, Smith U, Zierath JR, Mahlapuu M.Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet.FASEB J. 2013 Sep;27(9):3660-71.

Date of Defence: 2014-09-05
Disputation: Fredagen den 5 september 2014, kl 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: AMPK
Type 2 diabetes
Abstract: Type 2 diabetes mellitus (T2DM) is a widespread metabolic disorder that has reached epidemic proportions globally, and is now considered to be one of the main threats to human health. The currently available treatment options in T2DM suffer from inadequate efficacy and durability, as well as liabilities, including hypoglycemia, weight gain, edema and gastrointestinal intolerance. Since the efficacy and patient compliance of existing treatments are in many cases unsatisfactory, there is a pronoun... more
ISBN: 978-91-628-9067-4
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin



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