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The osteogenic potential of human mesenchymal stem cells: Novel markers and key factors for differentiation


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Title: The osteogenic potential of human mesenchymal stem cells: Novel markers and key factors for differentiation
Authors: Granéli, Cecilia
E-mail: cecilia.graneli@gu.se
cecilia.graneli@gmail.com
Issue Date: 14-May-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Biomaterials
Parts of work: I. Granéli C. et al. Virtual ligand-based screening reveals purmorphamine analogs with the capacity to induce the osteogenic differentiation of human mesenchymal stem cells. Cells Tissues Organs 2013;197(2):89–102.
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II. Granéli C. et al. The effects of PPAR-γ inhibition on gene expression and the progression of induced osteogenic differentiation of human mesenchymal stem cells. Connective Tissue Research 2014; Accepted for publication.

III. Granéli C. et al. Novel markers for osteogenic and adipogenic differentiation of human bone marrow stromal cells identified using a quantitative proteomics approach. Stem Cell Research 2014;12(1):153–165.
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IV. Omar O. et al. The stimulation of an osteogenic response by classical monocyte activation. Biomaterials 2011;32(32):8190-8204.
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V. Granéli C. et al. The effects of bacterial cell-wall components and bacterial membrane vesicles on the osteogenic differentiation and secretory profiles of human mesenchymal stem cells. In manuscript.
Date of Defence: 2014-05-09
Disputation: Fredagen den 9 maj, kl. 09.00. Sal 2118, Hus 2, Hälsovetarbacken.
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Mesenchymal stem cells
Mesenchymal stromal cells
Osteogenic differentiation
Adipogenic differentiation
Bone regeneration
Inflammation
Monocytes
Infection
Bacterial membrane vesicles
Compromised bone healing
Cell surface proteins
CD-markers
Osseointegration
Regenerative medicine
Abstract: Mesenchymal stem cells are multipotent stem cells with ability to differentiate into cells of the connective tissue lineage, such as adipocytes, osteoblasts and chondrocytes, both in vitro and in vivo. The main objective of the present thesis was to study different aspects of the osteogenic potential of MSCs. By examining markers of differentiation, exploring approaches for enhanced osteogenesis through the use of small molecule substances, and studying the interactions between MSCs and inflamma... more
ISBN: 978-91-628-8954-8 (tryckt bok)
978-91-628-8956-2 (pdf)
URI: http://hdl.handle.net/2077/35194
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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