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Liposarcomas - proliferation, senescence and the role of DDIT3


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Title: Liposarcomas - proliferation, senescence and the role of DDIT3
Authors: Kåbjörn Gustafsson, Christina
E-mail: christina.kabjorn@vgregion.se
Issue Date: 28-Feb-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Pathology
Parts of work: I. Katarina Engström, Helena Willén, Christina Kåbjörn Gustafsson, Carola Andersson, Marita Olsson, Melker Göransson, Sofia Järnum, Anita Olofsson, Elisabeth Warnhammar, Pierre Åman. The myxoid/round cell liposarcoma (MLS/RCLS) fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells. Am J Pathol 2006 168:5
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II. Christina Kåbjörn Gustafsson, Katarina Engström, Pierre Åman. DDIT3 expression in liposarcoma development. In revision, Sarcoma 2013

III. Christina Kåbjörn Gustafsson, Anders Ståhlberg, Katarina Engström, Anna Danielsson, Ingela Turesson, Pierre Åman. Cell senescence in myxoid/round cell liposarcoma. In revision, Sarcoma 2014

IV. Anders Ståhlberg, Christina Kåbjörn Gustafsson, Katarina Engström, Christer Thomsen, Soheila Dolatabadi, Emma Jonasson and Pierre Åman. Expression of normal and functional TP53 in myxoid liposarcoma/round cell liposarcoma. Submitted 2014

V. Christina Kåbjörn Gustafsson, Anders Ståhlberg, Pernilla Grundevik, Katarina Engström, Thoas Fioretos and Pierre Åman. Myxoid/round cell liposarcoma cell of origin and human muscle derived mesenchymal stem/precursor cells. In manuscript
Date of Defence: 2014-03-21
Disputation: Fredagen den 21 mars 2014, kl 9.00, Patologens aula, Ehrenströmsgatan 1 (Gula stråket 8)
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Liposarcoma
FUS-DDIT3
TP53
senescence
Abstract: Lipomatous tumors comprise benign and malignant forms called lipomas and liposarcomas. Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common liposarcoma and is characterized by the fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3. To understand the morphology of MLS we investigated the role of the FUS-DDIT3 fusion in the development of MLS/RCLS in FUS-DDIT3- and DDIT3-transfected human HT1080 sarcoma cells. Cells expressing FUS-DDIT3 and DDIT3 grew as liposarcomas in immune-deficient mice.... more
ISBN: 978-91-628 -8831-2
URI: http://hdl.handle.net/2077/34834
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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