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Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing


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Title: Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing
Authors: Thorfve, Anna
E-mail: anna.thorfve@biomaterials.gu.se
anna.thorfve@gmail.com
Issue Date: 10-Feb-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Biomaterials
Parts of work: I. Thorfve. A, Dehne, T, Lindahl, A, Brittberg, M, Pruss. A, Ringe. J, Sittinger. M, and Karlsson. C, Characteristic Markers of the Wnt Signaling Pathways Are Differentially Expressed in Osteoarthtitic Cartilage. Cartilage 2012; 3: 43-57.
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II. Svala. E, Thorfve. A, Ley. C, Barreto Henriksson. H, Synnergren. J, Lindahl. A, Ekman. S, and Skiöldebrand. E, Effects of Interleukin-6 and Interleukin-1β on Expression of Growth Differentiation Factor-5 and Wnt Signaling Pathway Genes in Equine Chondrocytes. Am J Vet Res 2014; 75: 132-140.
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III. Thorfve. A, Lindahl. C, Xia. W, Igawa. K, Lindahl. A, Thomsen. P, Palmquist. A, and Tengvall. P, Hydroxyapatite Coating Affects the Wnt Signaling Pathway during Peri-implant Healing in vivo. Acta Biomater 2014; 10: 1451-1462.
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IV. Thorfve. A, Bergstrand. A, Ekström. K, Lindahl. A, Thomsen. P, Larsson. A, and Tengvall. P, Gene Expression Profiling of Peri-implant Healing of PLGA-Li+ Implants Reveals an Activated Wnt Signaling Pathway in vivo. In manuscript.
Date of Defence: 2014-02-28
Disputation: Fredagen den 28 februari, kl 9.00, Hörsal 2118, Hus 2, HVB, Arvid Wallgrens backe, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Wnt signaling pathway
Osteoarthritis
Bone regeneration
Lithium
Abstract: The Wnt signaling pathway plays a central role in bone and cartilage embryonic development, processes that are recapitulated during regeneration. Imbalance in such well conserved and complex system often contributes to numerous diseases, whereas controlled modulation of the Wnt signaling activity is an attractive target e.g. for improved fracture healing therapies. The first aim of the present thesis was to increase the knowledge of the underlying mechanisms that lead to cellular alterations in ... more
ISBN: 978-91-628-8882-4 (Print)
978-91-637-4689-5 (Electronic)
URI: http://hdl.handle.net/2077/34433
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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