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Isolated regional perfusion for metastases of malignant melanoma - Clinical and experimental studies


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Title: Isolated regional perfusion for metastases of malignant melanoma - Clinical and experimental studies
Authors: Olofsson, Roger
E-mail: roger.olofsson@surgery.gu.se
Issue Date: 25-Oct-2013
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Surgery
Parts of work: I. Olofsson R et al. Long Term Follow-Up of 163 Consecutive Isolated Limb Perfusions for In-Transit Metastases of Malignant Melanoma. Int J Hyperthermia. 2013 Sep;29(6):551-7
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II. Olofsson R et al. Isolated Hepatic Perfusion for Ocular Melanoma Metastasis - Registry Data Suggests a Survival Benefit. Ann Surg Onc.
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III. Olofsson R et al. Melan-A specific CD8+ T lymphocytes after hyperthermic isolated limb perfusion: A pilot study in patients with in-transit metastases of malignant melanoma. Int J Hyperthermia. 2013 May;29(3):234-8
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IV. Eldh M, Olofsson R et al. MicroRNA in exosomes isolated from the liver circulation in patients with uveal melanoma metastases. Manuscript.
Date of Defence: 2013-11-15
Disputation: Fredagen den 15 november 2013, kl 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Malignant melanoma
Uveal melanoma
Isolated limb perfusion
Isolated hepatic perfusion
Immunology
Exosomes
Abstract: Background: Isolated regional perfusion is a treatment option mainly for localized metastatic disease. The principle idea is to surgically isolate a region of the body and connect the circulation to a heart-lung machine. A high concentration of a chemotherapeutic agent is then delivered to the tumour, while systemic toxicity is avoided. The aim of this thesis was to evaluate clinical outcome of isolated regional perfusion for extremity and liver metastases of malignant melanoma, investigate asso... more
ISBN: 978-91-628-8747-6
URI: http://hdl.handle.net/2077/33105
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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