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Allergenic Oxidation Products from Fragrance Terpenes. Chemical Analysis and Determination of Sensitizing Potency


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Title: Allergenic Oxidation Products from Fragrance Terpenes. Chemical Analysis and Determination of Sensitizing Potency
Authors: Rudbäck, Johanna
E-mail: johanna.rudback@chem.gu.se
Issue Date: 5-Sep-2013
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: I. Evaluation of ionization techniques for mass spectrometric detection of contact allergenic hydroperoxides formed by autoxidation of fragrance terpenes Johanna Nilsson, Josefina Carlberg, Peter Abrahamsson, Gustaf Hulthe, Bengt-Arne Persson, and Ann-Therese Karlberg Rapid Communications in Mass Spectrometry, 2008, 22, 3593-3598
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II. A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry Johanna Rudbäck, Nurul Islam, Ulrika Nilsson, and Ann-Therese Karlberg Journal of Separation Science, 2013, 36, 1370-1378
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III. Determination of allergenic hydroperoxides in essential oils using GC/electron ionization-MS Johanna Rudbäck, Ahmed Ramzy, Ann-Therese Karlberg, and Ulrika Nilsson Submitted for publication

IV. a-Terpinene, an antioxidant in Tea tree oil, autoxidizes rapidly to skin allergens on air exposure Johanna Rudbäck, Moa Andresen Bergström, Anna Börje, Ulrika Nilsson, and Ann-Therese Karlberg Chemical Research in Toxicology, 2012, 25, 713-721
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V. Citronellol – an underestimated fragrance allergen? Johanna Rudbäck, Lina Hagvall, Anna Börje, Ulrika Nilsson, and Ann-Therese Karlberg Manuscript
Date of Defence: 2013-09-27
Disputation: Fredagen den 27 september 2013, kl. 10.00, Sal KB, Institutionen för kemi, Kemigården 4, Göteborg
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Autoxidation
Contact allergy
Essential oils
Fragrances
Hydroperoxides
Ionization techniques
Mass spectrometry
Prehapten
Sensitization
Skin
Structure-activity relationships
Terpenes
Abstract: The ubiquitous presence of fragrance compounds in consumer products has resulted in a high frequency of contact allergy to fragrances in the population. For prevention purposes and according to EU regulations, cosmetics must be labeled when containing the most prominent fragrance allergens in concentrations exceeding 0.001% in “stay-on” products and 0.01% in “rinse-off” products. Previous studies have shown that the most common fragrance terpenes oxidize upon contact with air, forming hydroperox... more
ISBN: 978-91-628-8732-2
URI: http://hdl.handle.net/2077/32865
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

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