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Endocrine and diagnostic aspects of cognitive impairment


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Title: Endocrine and diagnostic aspects of cognitive impairment
Other Titles: with special reference to Alzheimer's disease
Authors: Johansson, Per M
E-mail: pmj@gu.se
per.m.johansson@telia.com
Issue Date: 30-Apr-2013
University: University of Gothenburg. Sahlgrenska Academy.
Institution: Institute of Medicine. Department of Internal Medicine
Parts of work: I. Cerebrospinal fluid biomarkers for Alzheimer’s disease – diagnostic performance in a homogeneous monocenter population. Johansson P§, Mattsson N§, Hansson O, Wallin A, Johansson JO, Andreasson U, Zetterberg H, Blennow K, Svensson J. §Contributed equally. J Alzheimers Dis. 2011; 24(3): 537-546.
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II. Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer’s disease. Johansson P, Åberg D, Johansson J-O, Mattsson N, Hansson O, Ahrén B, Isgaard J, Åberg ND, Blennow K, Zetterberg H, Wallin A, Svensson J. Psychoneuroendocrinology. 2013; Epub ahead of print.
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III. Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer’s disease. Johansson P, Almqvist EG, Johansson J, Mattsson N, Hansson O, Wallin A, Blennow K, Zetterberg H, Svensson J. Psychoneuroendocrinology. 2012; Epub ahead of print.
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IV. Mild dementia is associated with increased adrenal secretion of cortisol and precursor sex steroids in women. Johansson P, Johansson JO, Labrie F, Mattsson N, Hansson O, Blennow K, Zetterberg H, Wallin A, Ohlsson C, Svensson J. Clin Endocrinol (Oxf) 2011; 75(3):301-308.
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V. Leukocyte telomere length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's disease: a pilot study. Movérare-Skrtic S§, Johansson P§, Mattsson N, Hansson O, Wallin A, Johansson JO, Zetterberg H, Blennow K, Svensson J. §Contributed equally. Exp Gerontol 2012; 47(2):179-182.
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Date of Defence: 2013-05-17
Disputation: Fredagen den 17 maj 2013, kl. 09.00, Hörsal Ivan Östholm, Medicinaregatan 13 A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Hormones
Aging
Cerebrospinal
Alzheimer
Abstract: Hormones like insulin-like growth factor-I (IGF-I), thyroid hormones, and sex steroids decrease with normal aging. It is, however, unclear whether low hormone levels are related to age-related conditions such as Alzheimer’s disease (AD) or whether hormone levels are associated with markers of aging like leukocyte telomere length (LTL). The aims of this thesis were to validate cerebrospinal fluid (CSF) biomarkers in AD and to investigate whether hormonal aberrations might contribute to reduced c... more
ISBN: 978-91-628-8622-6
URI: http://hdl.handle.net/2077/32374
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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