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Volumetric assessment of hippocampus and cerebral white matter lesions in structural MRI


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Title: Volumetric assessment of hippocampus and cerebral white matter lesions in structural MRI
Authors: Olsson, Erik
E-mail: erik.olsson@neuro.gu.se
Issue Date: 2-Jan-2013
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: I. Olsson E, Eckerström C, Berg G, Borga M, Ekholm S, Johannsson G, Ribbelin S, Starck G, Wysocka A, Löfdahl E, Malmgren H: Hippocampal volumes in patients exposed to low-dose radiation to the basal brain. A case-control study in long-term survivors from cancer in the head and neck region. Radiation Oncology 2012, 7:202.
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II. Eckerström C, Olsson E, Borga M, Ekholm S, Ribbelin S, Rolstad S, Starck G, Edman A, Wallin A, Malmgren H: Small baseline volume of left hippocampus is associated with subsequent conversion of MCI into dementia: the Goteborg MCI study. J Neurol Sci 2008, 272:48-59
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III. Olsson E, Klasson N, Berge J, Eckerström C, Edman Å, Malmgren H, Wallin A: White matter lesion assessment in patients with cognitive impairment and healthy controls: reliability comparisons between visual rating, a manual and an automatic volumetrical MRI method - the Gothenburg MCI Study. J Aging Research,in press.
Date of Defence: 2013-01-22
Disputation: Tisdagen 22 januari 2013 kl 13.00, Hjärtats aula, huvudentrén, Blå stråket 5, Sahlgrenska universitetssjukhuset, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: structural MRI
white matter lesions
hippocampal volumetry
reliability
mild cognitive impairment
dementia
low dose radiation
Abstract: Assessment in structural MRI like hippocampal volumetry and white matter lesion (WML) assessment is receiving widespread attention and recommen-dation as important research and diagnostic tools. The aim in this thesis is to contribute to enhanced reliability and validity in structural MRI assessment. The hypothesis in Paper I was that long-term survivors of head and neck cancer with lowered quality of life had radiation induced damage to the hippocampus. The main hypothesis in Paper II was tha... more
ISBN: 978-91-628-8610-3
URI: http://hdl.handle.net/2077/31700
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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