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Non-linear Optical Microscopy and Spectroscopy for Biomedical Studies


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Title: Non-linear Optical Microscopy and Spectroscopy for Biomedical Studies
Authors: Guldbrand, Stina
E-mail: stina.guldbrand@physics.gu.se
Issue Date: 21-Nov-2012
University: Göteborgs universitet. Naturvetenskapliga fakulteten
Institution: Department of Physics ; Institutionen för fysik
Parts of work: Paper I: S.Guldbrand, C.Simonsson, M.Goksör, M.Smedh and M.B.Ericson. Two-photon fluorescence correlation spectroscopy combined with measurements of point spread function; investigations made in human skin, Optics Express, 18:15289 – 15302, 2010
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Paper II: S.Guldbrand, V.Kirejev, C.Simonsson, M.Goksör, M.Smedh and M.B.Ericson. Two-photon fluorescence correlation spectroscopy as a tool for measuring molecular diffusion within human skin, European Journal of Pharmaceutics and Biopharmaceutics, accepted in October,2012
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Paper III: D.Kantere, S.Guldbrand, J.Paoli, M.Goksör, D.Hanstorp, A.-M.Wennberg, M.Smedh and M.B.Ericson. Anti-Stokes fluorescence from endogenously formed Protoporphyrin IX – Implications for clinical multiphoton diagnostics, Journal of Biophotonics, accepted in August 2012
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Paper IV: S.Guldbrand, H.Evenbratt, J.Borglin, V.Kirejev and M.B.Ericson. Multiphoton induced luminescence from 10 nm gold nanoparticles – the effect of interparticle distance and aggregation Unpublished Manuscript
Date of Defence: 2012-12-12
Disputation: Onsdagen den 12 december 2012, kl 9:15, Kollektorn MC2, Kemivägen 9
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Two-Photon Excitation Microscopy
Fluorescence Correlation Spectroscopy
Multiphoton Luminescence
Human Skin
Gold nanoparticles
Abstract: This thesis is based on the application of non-linear optical microscopy and spectroscopy techniques within biomedical research. Non-linear optical microscopy gives the possibility of exciting fluorophores using near infrared light. This is an advantage when working with biological tissue, which has low absorption in this wavelength area, making up an ”open window”for non-invasive three dimensional imaging. Of particular interest has been the study of fluorescent xenobiotics in human skin ... more
ISBN: 978-91-628-8599-1
URI: http://hdl.handle.net/2077/30689
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för fysik

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