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The Renin Angiotensin System in the Human Esophageal Mucosa − expression, actions and potential involvement in reflux disease


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Title: The Renin Angiotensin System in the Human Esophageal Mucosa − expression, actions and potential involvement in reflux disease
Authors: Björkman, Eleonora
E-mail: eleonora.bjorkman@gastro.gu.se
ellen_bjorkman@hotmail.com
Issue Date: 30-Nov-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Gastrosurgical Research and Education
Parts of work: I. Björkman E, Casselbrant A, Lundberg S, Fändriks L. In vitro assessment of epithelial electrical resistance in human esophageal and jejunal mucosae and in Caco-2 cell layers. Scand J Gastroenterol. 2012 Nov;47(11):1321-33.
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II. Björkman E, Edebo A, Casselbrant A, Helander HF, Bratlie SO, Vieth M, Fändriks L. The renin angiotensin system in the esophageal mucosa of healthy subjects and patients with reflux disease. Accepted Scand J Gastroenterol. 2012.

III. Björkman E, Edebo A, Fändriks L, Casselbrant A. In vitro actions by angiotensin IV on the esophageal epithelium in healthy subjects and GERD patients. In manuscript
Date of Defence: 2012-12-21
Disputation: Fredagen den 21 december 2012, kl. 13.00, Hjärtats aula, Vita stråket 12, Sahlgrenska sjukhuset, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: endoscopic biopsies
epithelial electrical current
epithelial electrical resistance
esophageal mucosae
gastroesophageal reflux disease
mucosal barrier integrity
renin angiotensin system
Abstract: The renin angiotensin system (RAS) is a classical endocrine system, regulating body fluid balance and blood circulation. Recent research has shown that the system is being also locally expressed and active in several organs and tissues. Components of RAS have been discovered throughout the gastrointestinal tract and have, in addition, been found in the human esophagus. It was hypothesised that RAS could be of interest in relation to gastroesophageal reflux disease (GERD), which is a prevalent cl... more
ISBN: 978-91-628-8586-1
URI: http://hdl.handle.net/2077/30563
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

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