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ANALYSIS OF NOVEL BIOMARKERS FOR UNFAVORABLE BREAST CANCER PROGNOSIS


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Title: ANALYSIS OF NOVEL BIOMARKERS FOR UNFAVORABLE BREAST CANCER PROGNOSIS
Authors: Shubbar, Emman
E-mail: emman.shubbar@gu.se
Issue Date: 26-Nov-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Genetics
Parts of work: I. Petersson S, Shubbar E, Yhr M, Kovács A and Enerbäck C. Loss of ICAM-1 signaling induces psoriasin (S100A7) and MUC1 in mammary epithelial cells. Breast Cancer Res Treat. 2010; 125(1):13-25.
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II. Emman Shubbar, Jenny Vegfors, Maria Carlström, Stina Petersson and Charlotta Enerbäck, Psoriasin (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation Breast Cancer Res Treat. 2011; 134(1):71-80.
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III. Emman Shubbar, Anikó Kovács, Shahin Hajizadeh, Toshima Parris, Szilárd Nemes, Katrin Gunnarsdottir, Zakaria Einbeigi, Per Karlsson, and Khalil Helou, Elevated cyclin B2 expression in invasive breast carcinoma is associated with unfavorable clinical outcome Submitted, 2012

IV. Emman Shubbar, Khalil Helou, Anikó Kovács, Shahin Hajizadeh, Szilárd Nemes, Charlotta Enerbäck, and Zakaria Einbeigi, High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer. Submitted, 2012
Date of Defence: 2012-12-17
Disputation: Måndagen den 17 december 2012, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Ductal Carcinoma In Situ (DCIS)
Primary invasive breast cancer
Biomarkers
Abstract: Breast cancer is the most common malignancy in women, and a major cause of mortality and morbidity despite the advances in diagnosis and treatment. The main challenge remains to identify novel biomarkers in order to improve existing treatment modalities. Ductal carcinoma in situ (DCIS) is considered as a direct precursor of invasive breast cancer. Therefore, it would be valuable to be familiar with the natural history of DCIS, including how it develops, and if it will progress to invasive breast... more
ISBN: 978-91-628-8574-8
URI: http://hdl.handle.net/2077/30560
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

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