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Growth hormone and the heart in children

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Title: Growth hormone and the heart in children
Authors: Nygren, Anders
Issue Date: 9-Nov-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Pediatrics
Parts of work: I. Nygren A, Sunnegårdh J, Albertsson-Wikland K, Berggren H, Isgaard J. Relative expression of growth hormone receptor and insulin-like growth factor-I mRNA in congenital heart disease. J.Endocrinol Invest 2008;31:196-200.

II. Nygren A, Andersson B, Decker R, Nierop AF, Sunnegårdh J, Kriström B, Albertsson-Wikland K. Cardiac structure and function in short prepubertal children. Association with spontaneous GH secretion pattern and metabolic factors. Submitted to Clinical Endocrinology (Oxf) 2012.

III. Nygren A, Sunnegårdh J, Teien D, Jonzon A, Björkhem G, Lindell S, Albertsson-Wikland K, Kriström B. Rapid cardiovascular effects of growth hormone treatment in short prepubertal children. Impact of treatment duration. Clinical Endocrinology (Oxf) 2012, In Press.

IV. Decker R, Nygren A, Kriström B, Nierop A, Gustafsson J, Albertsson-Wikland K, Dahlgren J. Different thresholds of tissue-specific dose-responses to growth hormone in short prepubertal children. Accepted for publication in BMC Endocrine Disorders. 2012.
Date of Defence: 2012-11-30
Disputation: Fredagen den 30 november 2012, kl 13:00, föreläsningssal Tallen, Drottning Silvias barn och ungdomssjukhus, 416 85 Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Growth hormone secretion pattern
Cardiac dimensions
Growth hormone treatment
Abstract: Background and Aims: The fact that growth hormone (GH) influences cardiovascular structure and function is well established through both human and animal studies. Despite being secreted in a pulsatile fashion, only the impact of peak GH concentrations on cardiac parameters has previously been reported, and the time-dependency of cardiovascular effects during GH treatment has not been detailed. The aims of this pediatric study were (i) to establish the expression of GH-receptor (GH-R) and insulin... more
ISBN: 978-91-628-8552-6
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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