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Hypoxia and the Renin-Angiotensin System in Atherosclerosis

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Title: Hypoxia and the Renin-Angiotensin System in Atherosclerosis
Authors: Thalén Johansson, Cecilia
Issue Date: 6-Jul-2012
Degree: Student essay
Keywords: Atherosclerosis
renin-angiotensin system (RAS)
angiotensin II type 1 receptor (AT₁)
hypoxia inducible factor-1α (HIF-1α)
Abstract: Background – Cardiovascular disease is the leading cause of morbidity and mortality worldwide and atherosclerosis is estimated to be the underlying cause of approximately 50% of all deaths in western societies. Many aspects of the atherosclerotic disease are still incompletely characterized; it is commonly believed that inflammation is the driving force in development and progression of the disease and lately here has been increasing interest in the possible interplay between hypoxia and inflamm... more
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