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Psychological stress in relation to dementia and brain structural changes


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Title: Psychological stress in relation to dementia and brain structural changes
Authors: Johansson, Lena
E-mail: lena.johansson@neuro.gu.se
Issue Date: 3-Sep-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Audiology, Logopedics, Occupational Therapy & Physiotherapy
Parts of work: I. Lena Johansson, Xinxin Guo, Margda Waern, Svante Östling, Deborah Gustafson, Calle Bengtsson, Ingmar Skoog. Midlife Psychological Stress and Risk of Dementia: A 35-Year Longitudinal Population Study. Brain. 2010; 133:2217-24
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II. Lena Johansson, Ingmar Skoog, Deborah R Gustafson, Pernille J. Olesen, Margda Waern, Calle Bengtsson, Cecilia Björkelund, Leonardo Pantoni, Michela Simoni, Lauren Lissner, Xinxin Guo. Midlife Psychological Distress Associated With Late-Life Brain Atrophy and White Matter Lesions: A 32-Year Population Study of Women. Psychosomatic Medicine 2012; 74:120Y125
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III. Lena Johansson, Xinxin Guo, Tore Hällström, Maria C Norton, Margda Waern, Svante Östling, Calle Bengtsson, Ingmar Skoog. Common psychosocial life stressors in relation to perceived stress and Alzheimer’s disease over 38 years. (Unpublished manuscript)
Date of Defence: 2012-09-14
Disputation: Fredagen den 14 september 2012, kl. 13.00, Mölndalsaulan, V-huset, Mölndals sjukhus, Göteborgsvägen 31.
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Psychological stress
distress
psychosocial life stressors
dementia
Alzheimer's disease
vascular dementia
white matter lesions
brain atrophy
epidemiology
longitudinal study
risk factors
Abstract: Psychological stress has been recognized as an increasing public health problem with serious consequences in both physical and mental health. Women reported a higher prevalence of psychological stress, especially in midlife. Earlier studies suggested that psychological stress may cause neuronal degeneration and brain damage by changes in endocrine, metabolic, cardiovascular, and immune systems. The aim of this thesis was to examine whether midlife psychological stress and psychosocial life stre... more
ISBN: 978-91-628-8523-6
URI: http://hdl.handle.net/2077/29211
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

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