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Cerebral white matter changes in patients with cognitive impairment - clinical and pathophysiological aspects


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Title: Cerebral white matter changes in patients with cognitive impairment - clinical and pathophysiological aspects
Authors: Jonsson, Michael
E-mail: michael.jonsson@neuro.gu.se
Issue Date: 4-Apr-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: I. Jonsson M, Edman Å, Lind K, Rolstad S, Sjögren M, Wallin A. Apathy is a prominent neuropsychiatric feature of radiological white-matter changes in patients with dementia. (International Journal of Geriatric Psychiatry 2010 Jun;25(6):588-95).
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II. Jonsson M, Zetterberg H, van Straaten E, Lind K, Syversen S, Edman Å, Blennow K, Rosengren L, Pantoni L, Inzitari D, Wallin A. Cerebrospinal fluid biomarkers of white matter lesions – cross-sectional results from the LADIS study (European Journal of Neurology 2010, 17: 377-382).
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III. Jonsson M, Zetterberg H, Rolstad S, Edman Å, Gouw A, Bjerke M, Lind K, Blennow K, Pantoni L, Inzitari D, Wallin A. Low cerebrospinal fluid sulfatide predicts progression of white matter lesions – the LADIS study. (Submitted).

IV. Bjerke M, Jonsson M, Nordlund A, Gouw A, Blennow K, Zetterberg H, Pantoni L, Inzitari D, Schmidt R, and Wallin A. Cerebrovascular biomarker profile is related to white matter hyperintensities and ventricular atrophy in a LADIS substudy. (Manuscript).
Date of Defence: 2012-04-20
Disputation: Fredagen den 20 april, kl. 13.00, V-aulan, SU/Mölndal
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: white matter changes
vascular factors
cognitive impairment
neuropsychiatric symptoms
cerebrospinal fluid biomarkers
demyelination
axonal degeneration
Abstract: Cerebral white matter changes (WMC), detected with computed tomography (CT) or magnetic resonance imaging (MRI), represent a common condition in elderly people. However, the prognostic, symptomatological and biochemical constituents of WMC are only partially known. The aim of the present study was to evaluate WMC in relation to clinical manifestations in patients with mild cognitive impairment (MCI) and dementia and, by means of cerebrospinal fluid (CSF) analyses, to study different structural b... more
ISBN: 978-91-628-8447-5
URI: http://hdl.handle.net/2077/28482
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

 

 

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