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HIV Persistence and Viral Reservoirs
(2010-05-28)
Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting ...
On cerebrospinal fluid biomarkers of HIV-1 infection
(2015-11-26)
HIV invades the central nervous system (CNS) shortly after transmission and is present throughout the course of infection, causing immune activation and neuroinflammation. If left untreated, more than 20% of patients with ...
On HIV-1 latency and viral reservoirs
(2015-05-11)
HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and
anatomical reservoirs. This thesis concerns several problematic issues of HIV-1
persistence, including ways to measure and monitor ...
Inhibition of HIV-1 and HSV-2 infection by glycosaminoglycan mimetics
(2013-10-08)
HIV-1 is a sexually transmitted pandemic pathogen that causes progressive defects in cell-mediated immunity for which curative treatment and prophylaxis are lacking. In addition to CD4 and chemokine receptors of protein ...