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Protein Damage Control during Embryonic Stem Cell Differentiation: Role of the Proteasome


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Title: Protein Damage Control during Embryonic Stem Cell Differentiation: Role of the Proteasome
Authors: Hernebring, Malin
E-mail: malin.hernebring@med.lu.se
Issue Date: 11-May-2011
University: Göteborgs universitet. Naturvetenskapliga fakulteten
Institution: Department of Cell and Molecular Biology ; Institutionen för cell- och molekylärbiologi
Parts of work: I. Elimination of damaged proteins during differentiation of embryonic stem cells. Hernebring M*, Brolén G*, Aguilaniu H, Semb H & Nyström T. (2006) Proc Natl Acad Sci U S A. 103(20): 7700–7705. * contributed equally to this work
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II. Identification of Hsc70 as target for AGE modification in senescent human fibroblasts. Unterluggauer H, Micutkova L, Lindner H, Sarg B, Hernebring M, Nyström T & Jansen-Dürr P. (2009) Biogerontology. 10(3): 299-309.
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III. The proteasome activator PA28 is required for the removal of damaged proteins during differentiation of mouse embryonic stem cells. Hernebring M, Fredriksson Å, Norrman K, Rivett J, Wiseman J, Semb H & Nyström T. Manuscript.

IV. Effects of aging and reproduction on proteostasis in soma and gametes of Drosophila melanogaster. Fredriksson Å, Krogh-Johansson E, Hernebring M, Pettersson E & Thomas Nyström. Manuscript.
Date of Defence: 2011-06-01
Disputation: onsdagen den 1 juni 2011 kl. 10.00 i Carl Kylberg, Institutionen för Cell- och Molekylärbiologi, Medicinaregatan 7B, Göteborg
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Embryonic Stem Cells
Proteasome
Protein Carbonylation
Advanced Glycation End products
Cell Differentiation
Oxidative stress
Aging
RNAi
Abstract: During the lifespan of organisms ranging from yeast to humans, there is an accumulation of macromolecular damage. However, these organisms produce youthful progeny with low damage levels. This thesis focuses on how this is accomplished. I have analyzed whether the levels of oxidatively damaged proteins change in mouse embryonic stem (ES) cells during the initial steps of cell specification (differentiation) from the pluripotent state. The results show that ES cells contain high levels of prot... more
ISBN: 978-91-628-8309-6
URI: http://hdl.handle.net/2077/25294
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för cell- och molekylärbiologi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

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