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Renal hemodynamics in renal artery stenosis and angiotensin II-dependent hypertension. Pathophysiological and diagnostic aspects.


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Title: Renal hemodynamics in renal artery stenosis and angiotensin II-dependent hypertension. Pathophysiological and diagnostic aspects.
Authors: Aso, Saeed
E-mail: aso.saeed@vgregion.se
Issue Date: 26-May-2011
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: I. Aso Saeed, Göran Bergström, Karin Zachrisson, Gregor Guron, Elzbieta Nowakowska-Fortuna, Ellen Fredriksen, Lars Lönn, Gert Jensen, Hans Herlitz. Accuracy of colour duplex sonography for the diagnosis of renal artery stenosis. Journal of Hypertens. 2009:27(8):1690-6.
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II. Aso Saeed, Gerald F. DiBona, Niels Marcussen, Gregor Guron. High NaCl intake impairs dynamic autoregulation of renal blood flow in angiotensin II-infused rats. American journal of physiology Regulatory, integrative and comparative physiology.2010 Nov;299(5):R1142-9.
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III. Aso Saeed, Hans Herlitz, Elzbieta Nowakowska-Fortuna, Ulf Nilsson, Alaa Alhadad, Gert Jensen, Ingrid Mattiasson, Bengt Lindblad, Anders Gottsäter, and Gregor Guron. Oxidative stress and endothelin-1 in atherosclerotic renal artery stenosis and effects of renal angioplasty. (In press, Kidney and Blood Pressure Research)

IV. Aso Saeed, Gerald F. DiBona, and Gregor Guron. Effects of endothelin receptor antagonists on renal hemodynamics in angiotensin II-infused rats on high NaCl intake. (Submitted)
Date of Defence: 2011-06-09
Disputation: Torsdagen, den 9 juni 2011, kl. 09:00, Hjärtats aula, Blå stråket 5,Sahlgrenska Universitetssjukhuset/Sahlgrenska, Göteborg,
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: angiotensin II
autoregulation of renal blood flow
color duplex sonography
endothelin-1
oxidative stress
renal artery stenosis
renal hemodynamics
renovascular hypertension
Abstract: Patients with renovascular hypertension have a poor renal and cardiovascular prognosis. To improve the care of these patients, we need to increase knowledge about the pathophysiological mechanisms involved. Thus, the aims of these studies were to examine: (1) renal hemodynamics and renal blood flow autoregulation (RBFA) in an experimental model of chronic angiotensin (Ang) II-dependent hypertension and the role of superoxide and endothelin (ET)-1; (2) the diagnostic value of intrarenal velocim... more
ISBN: 978-91-628-8295-2
URI: http://hdl.handle.net/2077/24853
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för medicin
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

 

 

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