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Structure and Function of Aqua(glycero)porins - A Path to Drug Design


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Title: Structure and Function of Aqua(glycero)porins - A Path to Drug Design
Authors: Fischer, Gerhard
E-mail: gerhard.fischer@chem.gu.se
Issue Date: 5-Apr-2011
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry ; Institutionen för kemi
Parts of work: Törnroth-Horsefield S, Hedfalk K, Fischer G, Lindkvist-Petersson K, Neutze R. “Structural insights into eukaryotic aquaporin regulation.” FEBS Letters. 582(12), 2580-2588 (2010). Review.
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Fischer G, Kosinska-Eriksson U, Aponte-Santamarìa C, Palmgren M, Geijer C, Hedfalk K, Hohmann S, de Groot B, Neutze R, Lindkvist-Petersson K. “Crystal Structure of a Yeast Aquaporin at 1.15 Å reveals novel gating mechanism.” PLoS Biology. 7(6); (2009)
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Kosinska-Eriksson U, Fischer G, Friemann R, Neutze R. “Sub-atomic Resolution Structure of a Yeast Aquaporin Reveals a Low-barrier Mechanism for Selective Water Transport.”, manuscript

Fischer G, Kosinska-Eriksson U, Neutze R. “Ambient temperature crystal structure of a yeast aquaporin implies mechanosensitive gating.”, manuscript

Brändén M, Tabaei SR, Fischer G, Neutze R, Höök F. “Refractive-Index Based Screening of Membrane-Protein Mediated Transfer across Biological Membranes.” Biophysical Journal. 99(1), 124-133 (2010)
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Fischer G, Moberg A, Sjöhamn J, Tabaei SR, Brändén M, Höök F, Hedfalk K, Fishwick C, Johnson P, Neutze R, Simmons K. “Discovery of Inhibitors of the Aquaglyceroporin of Plasmodium falciparum using Virtual High-throughput Screening and a Novel in vitro Method for Membrane Protein Channels.”, manuscript
Date of Defence: 2011-04-29
Disputation: Fredagen, den 29 april 2011, kl. 9.00, Hörsal KA, Kemihuset, Kemigården 4
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: structural biology
drug screening
Malaria
membrane proteins
yeast
Abstract: Membrane proteins are a major class of the drug targets. Rational design of drugs requires knowledge about the structure and function of these proteins. Working with membrane proteins, however, is experimentally challenging as the required technology is still emerging. Water being the medium of life, Nature has evolved specialized water channels called aquaporins. These transporters are found in all kingdoms of life – from simple microorganisms to humans – and function to maintain water homeos... more
ISBN: 978-91-628-8267-9
URI: http://hdl.handle.net/2077/24754
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för kemi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

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