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Exact Semiparametric Inference About the Within-Subject Variability in 2 x 2 Crossover Trails.


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Title: Exact Semiparametric Inference About the Within-Subject Variability in 2 x 2 Crossover Trails.
Authors: Guilbaud, Olivier
Issue Date: 1-Mar-1992
Extent: 28
Publication type: report
Publisher: University of Gothenburg
Series/Report no.: Research Report
1992:3
Keywords: Kendall's tau
simultaneous inferences
multiple test procedure
bioequivalence
Abstract: The comparison of primary interest in a 2 x 2 crossover trial typically concerns the effect of the treatments, say A and B, on the mean response level. This article deals with another important aspect, namely the within-subject response variability under A and B. Differences in drug formulation and/or administration may lead to considerable differences in withinsubject variability, whatever is the difference in terms of mean level; and consideration of both these aspects may therefore be of cons... more
ISSN: 0349-8034
URI: http://hdl.handle.net/2077/24615
Appears in Collections:Research Report

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