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Functions of glycoprotein G of herpes simplex virus type 2


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Title: Functions of glycoprotein G of herpes simplex virus type 2
Authors: Görander, Staffan
E-mail: staffan.gorander@gu.se
Issue Date: 19-Feb-2010
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Infectious Medicine
Parts of work: I. Görander S, Svennerholm B, Liljeqvist J-Å. Secreted portion of glycoprotein g of herpes simplex virus type 2 is a novel antigen for type-discriminating serology. J Clin Microbiol. 2003:41(8):3681-6.
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II. Görander S, Mbwana J, Lyamuya E, Lagergård T, Liljeqvist J-Å. Mature glycoprotein g presents high performance in diagnosing herpes simplex virus type 2 infection in sera of different tanzanian cohorts. Clin Vaccine Immunol. 2006 Jun;13(6):633-9.
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III. Liljeqvist J-Å, Görander S, Elias P, Aslani A, Bergström T. (2010). Glycoprotein G of herpes simplex virus type 2 is essential for neuronal spread of genital infection in mice. In manuscript.

IV. Görander S, Lindqvist M, Harandi A, Liljeqvist J-Å. (2010). Vaccination with the mature glycoprotein G of herpes simplex virus type 2 protects against genital and neurological disease. In manuscript.
Date of Defence: 2010-03-12
Disputation: Fredagen den 12 mars 2010 kl. 09.00, mikrobiologens föreläsningssal, Guldhedsgatan 10 A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Herpes simplex virus type 2
glycoprotein G-2
type specific serology
vaccine
Tanzania
Abstract: Background: Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted infection with more than 500 million individuals infected world-wide. A major global health problem is that HSV-2 infection facilitates the spread of HIV. This epidemiological situation warrants the development of a vaccine to reduce the spread of HSV-2. As HSV-2 often is transmitted without symptoms type specific serology is valuable in diagnosis of the infection. The envelope glycoprotein G (gG-2) of HSV-2 is clea... more
ISBN: ISBN 978-91-628-8005-7
URI: http://hdl.handle.net/2077/21861
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

 

 

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