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Genetics of Parkinson's disease - with focus on genes of relevance for inflammation and dopamine neruon development


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Title: Genetics of Parkinson's disease - with focus on genes of relevance for inflammation and dopamine neruon development
Authors: Zettergren, Anna
E-mail: anna.zettergren@pharm.gu.se
Issue Date: 18-Feb-2010
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Pharmacology
Parts of work: I. Westberg L, Håkansson A, Melke J, Shahabi HN, Nilsson S, Buervenich S, Carmine A, Ahlberg J, Grundell MB, Schulhof B, Klingborg K, Holmberg B, Sydow O, Olson L, Johnles EB, Eriksson E, Nissbrandt H. Association between the estrogen receptor beta gene and age of onset of Parkinson’s disease. Psychoneuroendocrinology 2004; 29: 993-998.
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II. Håkansson A, Westberg L, Nilsson S, Buervenich S, Carmine A, Holmberg B, Sydow O, Olson L, Johnels B, Eriksson E, Nissbrandt H. Interaction of polymorphisms in the genes encoding interleukin-6 and estrogen receptor beta on the susceptibility to Parkinson’s disease. American Journal. of Medical Genetics (Part B) 2005; 13: 88-92.
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III. Håkansson A, Westberg L, Nilsson S, Buervenich S, Carmine A, Holmberg B, Sydow O, Olson L, Johnels B, Eriksson E, Nissbrandt H. Investigation of genes coding for inflammatory components in Parkinson’s disease. Movement Disorders 2005; 20: 569-573.
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IV. Håkansson A, Bergman O, Chrapkowska C, Westberg L, Carmine Belin A, Sydow O, Johnels B, Olson L, Holmberg B, Nissbrandt H. Cyclooxygenase-2 polymorphisms in Parkinson’s disease. American Journal of Medical Genetics (Part B) 2007; 144: 367-369.
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V. Håkansson A, Carmine Belin A, Stiller C, Sydow O, Johnels B, Olson L, Holmberg B, Nissbrandt H. Investigation of genes related to familial forms of Parkinson’s disease - With focus on the Parkin gene. Parkinsonism and Related Disorders 2008; 14: 520-522.
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VI. Bergman O, Håkansson A, Westberg L, Nordenström K, Carmine Belin A, Sydow O, Olson L, Holmberg B, Eriksson E, Nissbrandt H. PITX3 polymorphism is associated with early onset Parkinson’s disease. Neurobiology of Aging 2010; 31: 114-117.
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VII. Bergman O, Håkansson A, Westberg L, Carmine Belin A, Sydow O, Olson L, Holmberg B, Fratiglioni L, Bäckman L, Eriksson E, Nissbrandt H. Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson’s disease? Journal of Neural Transmission 2009; 116: 333-338.
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Date of Defence: 2010-03-11
Disputation: Torsdagen den 11 mars 2010, kl. 13.00, Föreläsningssalen Ivan Östholm, LNC, Medicinaregatan 13
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Parkinson's disease
genetics
inflammation
single nucleotide polymorphism
dopamine neuron development
estrogen
gene
age of onset
Pitx3
estrogen receptor beta
interleukin 6
Abstract: Abstract GENETICS OF PARKINSON’S DISEASE - WITH FOCUS ON GENES OF RELEVANCE FOR INFLAMMATION AND DOPAMINE NEURON DEVELOPMENT Introduction: The risk to be affected by Parkinson’s disease (PD) is considered to be influenced by genetic factors. In some rare cases of familial PD, mutations in some specific genes are known to cause the disease, but in the more common sporadic form of PD the causes are probably environmental factors interacting with genetic vulnerability. The main objective o... more
ISBN: 978-91-628-8022-4
URI: http://hdl.handle.net/2077/21538
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

 

 

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