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Artificial blood vessels - Studies on endothelial cell and blood interactions with bacterial cellulose


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Title: Artificial blood vessels - Studies on endothelial cell and blood interactions with bacterial cellulose
Authors: Fink, Helen
E-mail: helen.fink@wlab.gu.se
Issue Date: 13-Nov-2009
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Surgery
Parts of work: I. Bodin A, Bäckdahl H, Fink H, Brumer H, Risberg B, Gatenholm P. Modification of Nanocellulose with a Xyloglucan-RGD Conjugate Enhances Adhesion and Proliferation of Endothelial Cells: Implications for Tissue Engineering. Biomacromolecules. 2007 Dec;8(12):3697-704.
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II. Fink H, Ahrenstedt L, Bodin A, Brumer H, Gatenholm P, Krettek A, Risberg B. Bacterial cellulose modified with xyloglucan bearing the adhesion peptide RGD promotes endothelial cell adhesion and metabolism - a promising modification for vascular grafts. Submitted

III. Fink H, Faxälv L, Molnar G, Drotz K, Risberg B, Lindahl T, Sellborn A. Real time measurements of coagulation on bacterial cellulose and conventional vascular graft materials. Acta Biomaterialia 2009.
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IV. Fink H, Hong J, Drotz K, Risberg B, Sanchez J, Sellborn A. An in vitro study of blood compatibility of bacterial cellulose. Manuscript

V. Fink H, Skog A, Drotz K, Redl H, Risberg B, Gatenholm P. In vitro evaluation of endothelial cells on fibrin-coated Bacterial cellulose exposed to shear stress. Manuscript
Date of Defence: 2009-11-27
Disputation: Fredagen den 27 november 2009, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: bacterial cellulose
endothelial cells
thrombogenicity
xyloglucan
contact activation
imaging of coagulation
vascular grafts
RGD
cell adhesion
bioreactor
Abstract: Cardiovascular diseases are still the number one cause of death or invalidity in the western world today. Atherosclerotic plaques and restenosis can result in severe occlusions of peripheral and coronary arteries. Treatment depends on the severity of the disease and includes drug therapy and bypass surgery. Generally, autologous vessels are used as replacement grafts and are the first choices as vascular graft materials. However, if the patient does not have vessels with sufficient quality, as a... more
ISBN: 978-91-628-7941-9
URI: http://hdl.handle.net/2077/21217
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

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